Study On The Relativity Of Blood Gamma-glutamyl Transferase Level And Intra-and Extracranial Artery Stenosis,Recurrence In Patients With Cerebral Infarction

ObjectiveTo evaluate the relativity of blood Gamma-glutamyl Transferase(GGT) level and intracranial and extracranial artery stenosis, recurrence in patients with cerebral infarctionMethodsAccording to computerized tomography angiograph(CTA),total of 163 cerebral infarction inpatients were divided into intracranial and extracranial artery with or without stenosis group. Then the blood GGT levels and age, male, smoking, hypertension, diabetes, blood lipid and other risk factors associated with atherosclerosis stenosis were compared among groups. Again using multiariable Logistic regression equation analysis the correlation of them and intracranial and extracranial atherosclerotic stenosis.Then according to the degree of stenosis,all inpatients were divided into mild stenosis group, moderate stenosis group, severe stenosis or occlusion group, and compared three groups of GGT level.According to the patients ever confirmed, all of the patients with cerebral infarction were divided into incipient and relapse group,then compared two groups of artery stenosis rate, degree of stenosis,GGT levels and other risk factors.Then used multiariable Logistic regression equation to analysis the correlation of risk factors and recurrent cerebral infarction.Results:1 Artery stenosis groups of age, male, hypertension, diabetes, smoking, systolic bloodpressure,low density lipoprotein(LDL) and GGT levels, respectively, compared with control group was significant(P < 0.05). The levels of blood GGT of pure extracranial artery stenosis group and simple intracranial stenosis group showed no significant difference(P > 0.05). Total cholesterol(TCH), high-density lipoprotein cholesterol(HDL) and fasting plasma glucose(FPG) between four groups had no statistical significance(P > 0.05); Triglycerides(TG) of intracranial and extracranial artery stenosis group was significantly higher than control group(P < 0.05).Logistic regression analysis showed that the P of GGT for cranial artery stenosis disease was 0.003,which showed statistic significance. 2 Blood GGT levels in the group of mild stenosis, moderate stenosis, severe stenosis or occlusion group was 48.64±19.65u/L, 56.75±17.78u/L and 62.00±25.40 u/L, the difference was statistically significant(P<0.05). 3 Incipient group had 65(63.7%) patients with artery stenosis while relapse group had 37(36.3%) patients with artery stenosis.The comparison results had statistical significance(P < 0. 01).Relapse group of patients with mild stenosis ratio was lower than the incipient group, the difference had statistical significance(P < 0. 01);Relapse group of patients with severe stenosis ratio was higher than the incipient group, the difference was statistically significant(P < 0.01). 4 Compared with incipient group, the age, number of smoker, hypertension, diabetes, systolic blood pressure,LDL and GGT levels of relapse group are higher,and the difference had statistical significance(P < 0.05). Logistic regression analysis showed that age(P < 0.001), systolic blood pressure,LDL and GGT(P<0.01) on cerebral infarction recurrence was statistically significant.Conclusion1 The blood GGT levels and cranial atherosclerotic stenosis are closely related.GGT is an independent risk factor for the cranial stenosis and no significant difference inintracranial or extracranial artery injury. 2 An increase in blood GGT level of patients with cerebral infarction predicts the increasing degree of cranial atherosclerotic stenosis. 3 The artery stenosis rate and the degree of stenosis are higher in patients with recurrent cerebral infarction than in incipient cerebral infarction. 4 Elevated blood GGT levels may be risk factors for recurrence of cerebral infarction.