| ObjectiveCardiovascular disease risk factors in China popular trend obviously, led to the increase of the onset of cardiovascular disease. Overall, cardiovascular disease prevalence in the rising stage in our country. Coronary heart disease has become a danger to the largest killer of human health. And coronary heart disease (CHD) in cardiovascular disease is a major disease endangering human health, has close ties to the diabetes and coronary heart disease patients with coronary heart disease (CHD) combined the higher percentage of sugar metabolic abnormalities, clinical symptoms are not typical, case fatality rate is high, the prognosis is poor, clinical complications much and control effect is poor. Since put forward the concept of vascular endothelial His1865 years, more and more studies have shown that vascular endothelial damage in a variety of the onset of cardiovascular disease, and that the disorder of vascular endothelium is initiating factor in atherosclerosis first. Now, the study found that elderly coronary heart disease and coronary heart disease, diabetes mellitus had existed vascular endothelial dysfunction, and coronary heart disease patients with diabetes mellitus endothelial dysfunction is more serious, vascular endothelial cells throughout the course of the coronary heart disease (CHD) with sugar metabolic abnormalities disease so improving vascular endothelial function, control blood sugar is one of the important measures to reduce cardiovascular events. Coronary heart disease (CHD) with the sugar metabolic abnormalities in patients with vascular endothelial function, a series of harmful factors in endothelial cells release of shu vascular factor decreases, shrinkage vascular factor increased, broken blood vessels are balanced steady state, eventually lead to a series of the happening of cardiovascular events. In vascular endothelial damage, small concave protein Caveolin-1 the most closely relationship with coronary heart disease, diabetes, and Caveolin-1 as a common channel, both in coronary heart disease (CHD) with abnormal glucose metabolism plays an important role. Both have the same evidence, based on "different development" theory of traditional Chinese medicine, discusses this topic from Caveolin-1 mindarmor party vascular endothelial damage in patients with coronary heart disease (CHD) with sugar metabolic abnormalities, from the perspective of endothelial injury to explore coronary heart disease (CHD) with sugar metabolic abnormalities in patients with evidence of modern medicine. At the same time provide objective way to improve clinical curative effect of traditional Chinese medicine. And is the research of traditional Chinese medicine treatment of serious diseases to provide new targets and train of thought, has the dual value of theory and application.MethodsUse prospective randomized single blind controlled clinical research method, using the design of the second group, screening diagnosis for patients with coronary heart disease, such as previous confirmed directly into type 2 diabetes as a drug test subjects, there is no history of diabetes patients OGTT test, sugar metabolic abnormalities as a drug test subjects, patients with no sugar metabolic abnormalities were not included in the drug test, but as a baseline control group. Drug trial subjects randomized, divided into control group and treatment group, control group treated by routine western medicine, on the basis of control group and treatment group with heart guard TCM formula granules, a course of 20 days, all of the patients into the drug trial therapy before (and correcting baseline control group),10 days,20 days fill in testing related respectively, CRP and blood sample inspection, cav 1, way of eNOS related indicators, and the results were statistically analyzed.Results1. Two groups of patients with baseline data comparison, but there was no difference in the two groups of patients in such aspects as age/gender, comparable.2. Coronary heart disease (CHD) with sugar metabolic abnormalities in patients with CRP, cav 1 expression level obviously higher than that of pure coronary heart disease patients, the t test, (t< 0.05), the difference is statistically significant. That both merge, the expression level is significantly higher than pure patients with coronary heart disease (CHD).3. Comparison of TCM syndrome integral, the treatment group before and after its TCM syndrome integral,10/20 days after treatment than before treatment were significantly decreased, but the scores 20 days fell more obvious, the t test, p values are less than 0.05, the difference was statistically significant. Control group before and after their contrast,10 and 20 days of TCM syndrome in patients with integral have the same drop, by comparison,20 days of TCM syndrome in patients with integral decreased significantly earlier. The t test, p values were less than 0.05, the difference was statistically significant. Two groups of patients with TCM syndrome integral are lower than before treatment, can think of no matter simple routine treatment group and conventional treatment+armor heart, has a better therapeutic effect.10 days after treatment in both groups/20 day average CRP, by t test, (p value is less than 0.05) difference was statistically significant. So in terms of CRP expression, conventional treatment to protect the heart side is relatively pure western medicine routine treatment effect is remarkable.Conelusion1. The expression of CRP and cav 1 in patients with coronary heart disease (CHD) with sugar metabolic abnormalities are relatively simple in patients with coronary heart disease increased significantly, and with the progress of the treatment, the illness alleviates the fall, tip has certain correlation index and disease condition, in the process of coronary heart disease treated with sugar metabolic abnormalities, CRP and cav 1 can be used for monitoring condition change and evaluation index of curative effect.2. Protect heart party merger sugar metabolic abnormalities have exact curative effect, treatment of the coronary heart disease, there was no obvious side effects, its mechanism of action could be Caveolin could regulate the activity of NOS, and participate in the regulation of insulin signaling pathway, inhibiting the inflammatory response, thus improving vascular endothelial cells. |
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