| ObjectiveIn recent years, the domestic and foreign research found that recurrent spontaneous abortion(RSA) was gradually rising trend. Its mechanism is not very clear and the incidence of complex factors has become one of the impact on women’s physical and mental health disorders. This research is to explore the effect of Chinese medicine in the prevention and treatment of the RSA of kidney and spleen deficiency by observing the clinical effect with Zishenyutaiwan trenting the RSA of kidney and spleen deficiency, and also to prevent the RSA and to guide prenatal and postmatal care.MethodsThe selected cases were finished between December 2013 to December 2014, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine gynecological outpatient and ward diagnostic RSA in patients with kidney and spleen deficiency, a total of 60 cases were equally divided into trentment group and control group. The trentment group is to start to take Zishenyutaiwan after the RSA of curettage or self complete abortion with urinary HCG negative, taking 3 consecutive months,each time 5g(about 2/3 cap), with light salt water delivery service,3 times a day, stopping drugs during menstruation, pregnancy again after 3 months, and continuing to take 3 months after the pregnancy. The control group will be composed of the RSA patients with 2 or more times and without systematic trentment. The trentment group patients will be followed up for 3 months before and after pregnancy, observing and recording the improvement of kidney and spleen deficiency syndrome before and after pregnancy and HCG, P and B ultrasound conditions after pregnancy, and only observying and recording the improvement of kidney and spleen deficiency syndrome for non pregnant patients. The control group will be followed up for 3 months after pregnancy, observing and recording the improvement of kidney and spleen deficiency syndrome and HCG, P and B ultrasound conditions after pregnancy. Finally, carrying on the statisticl analysis to observe the clinical effect of Zishenyutaiwan trenting the recurrent embryo development ceasing of kidney and spleen deficiency.ResultsIn the 30 cases of trentment group patients, the clinical symptoms of 25 cases were reduced in different degrees, including 15 cases of successful pregnancy;the clinical symptoms of 4 cases have eased, of which 2 cases happening again embryo development ceasing; 1 case unable to follow up as a result of mobile phone number erpired. The causes of 25 cases occurred RSA patients,15 cases were of unknown csuses,5 cases were immune factors,2 cases of endocrine factors,1 case of infection factors,1 case of immune combined endocrine factors,1 case of immune associated with infection factors. The causes of 5 cases occurred RSA patients,4 cases were of unknown csuses,1 cases of endocrine factors.In the 30 cases of control group patients, the clinical symptoms of 11 cases were reduced in different degrees and successfully pregnanted, and the clinical symptoms of 19 cases had eased and reappeared RSA.The causes of 11 cases of successful pregnancy occurred in RSA,6 cases were of unknown causes,3 cases were immune factors,2 cases were endocrine factors. The causes of 19 cases of failurebale pregnancy occurred in RSA,13 cases were of unknown causes,4 cases were immune factors,2 cases were endocrine factors.1 case of infection factors,1 case of immune combined infection factors.After treatment, the trentment group of patients the TCM symptoms score treatment were significantly lower than before, with statistical significance (P< 0.01). And the trentment group was no obvious adverse reaction.After treatment,15 cases of the trentment group were successfully pregnanted, and the pregnanted rate was 50%.11 cases of the control group were successfully pregnanted, and the pregnanted rate was 36.67%. There was no significant difference between the two groups of patients with the pregnanted rate (P>0.05)After treatment,2 cases of the trentment group were occurred spontaneous abortion, and the abortion rate was 6.67%.19 cases of the control group were occurred spontaneous abortion, and the abortion rate was 63.33%. There was significant difference between the two groups of patients with the abortion rate (P<0.01).The clinical total effective rate of the trentment group was 83.33%, the control group total effective rate was 36.67%. There was significant difference between the two groups of patients with clinical efficacy (P< 0.01). This shows that the trentment group has better clinical effect.Conclusion1.The clinical symptoms of the recurrent embryo development ceasing of kidney and spleen deficiency can be significantly improved by the use of Zishenyutaiwan, and can make the patients pregnant successfully.2. There are not obvious adverse reaction in the treatment of the recurrent embryo development ceasing of kidney and spleen deficiency patients with Zishenyutaiwan, and this shows that Zishenyutaiwan is safe and relatively that it is worth in clinical promotion and application. |
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