The Mechanism And CliniCaiStud Ies Of Qian Tong Ding Decoction Intervention On Lllb Chornic Prostatitis Pain

ObjectiveThis topic through the observation Qian Tong Ding decoction in the tr-eatment of Ⅲb Chornic prostatitis clinical curative effect and the poiso-nous side effect, aims to explore the mechanism of Qian Tong Ding decoction intervention on the Ⅲb Chornic prostitutes pain, further affirmed Qian Tong Ding decoction clinical curative effect of Ⅲb Chornic prostitutes. Make a useful exploration of Chinese medicine in the treatment of prostatitis clinic-al drugs, new ideas.MethodThe 60 cases of Ⅲb Chornic prostatitis patients according to treatment time were randomly assigned to the G1, G2, G3 group with the block randomization method. G1 group was treated with Qian Tong Ding decoction, G2 group was treated with tamsulosin hydrochloride sustained-release capsules, and G3 group oral Qian Tong Ding decoction and tamsulosin hydrochloride sustained-release Ca-psules, that are a course of a month. Each patient was observed NIH chronic prostatitis symptom index symptom score (NIH-CPSI), pain and discomfort scores and TNF-a, IL-10 change of EPS, assessing efficacy, and record all adverse situations arise during the experiment.Result①NIH-CPSI score and pain and discomfort Rating:three groups were sign-ificantly lower after treatment and it was statistically significant (P<0.05); after treatment, G2 group had significant differences compared with Gl and G3 group (P<0.05), Gl group compared with G3 group, it had no significant di-fference (P> 0.05). ②TNF-a:There were significant reduction in the three groups after treatment compared with before treatment(P<0.05); after tre-atment, G1, G3 group compared with G2 group were significantly different (P <0.05), G1 group compared with G3 group, There was no difference (P> 0.05). IL-10:After treatment, within the group, G1, G3 group before treatment showed an upward trend, there was a significant difference (P<0.05), after treatment, G2 grou had no significant difference (P> 0.05); group comparison between the three groups were not significantly different (P> 0.05).③ After treatment, G1 group,20 patients were cured 3cases,11 cases markedly effective in 3 cases, 3 cases, the total efficiency of 85.00%; G2 group of 20 patients were cured 2 cases, effective in 4 cases, effective in 7 cases,7 cases, the total eff-iciency of 65.00%, G3 group of 20 patients were cured 3 cases,12 cases markedly effective in 4 cases,1 cases, the total efficiency of 95.00%. After 1 month treatment, Gl, G3 compared with G2 group there was a significant difference (P<0.05).④ the course of treatment, G1 group found two cases of loose stools; G2 group had one case of anorexia, one cases of blood pressure; G3 group of one cases of patients with loose stools,one case of dizziness.GonclusionQian Tong Ding decoction can Significantly improve Clinical symptoms Mainly with pain of Ⅲb Chornic prostatitis patients, significantly reduce NIH-CPSI scores, Improve the quality of life of patients. Its analgesic mec-hanism may be related to the expression of inflammatory cytokines participate neural regulation process on pain.