Fibro Scan Clinical Application In Chronic Liver Disease And The Correlation Of Fibro Scan With TCM Syndrome

Objectives:To observe the liver stiffness measurement(LSM)vary in different clinical stages of chronic liver disease, explore the relativity of Fibro Scan with liver fibrosis’ s diagnosis, assessment, and TCM Syndromes, provide clinical technical date for chronic liver disease diagnosis and treatment.Methods:Select 316 cases from patients with chronic liver disease met the diagnostic criteria, conduct Fibro Scan, ICG test, medical index examination, abdominal ultrasonography and detect TCM Syndrome. Investigate the application of LSM in chronic liver disease, analysis of correlation between LSM and TCM syndrome types, the relevance between LSM and related medical indicators will also be analyzed.Results:1. LSM values related to PCIII, C-IV, HA, LN, ALT, AST, TB, DB, PT and APRI showed a positive correlation, negative correlation with the ALB, PLT, ALT/AST showed.2. Chronic hepatitis, liver cirrhosis and decompensated cirrhosis patients with LSM values in ascending order, there was a significant difference between the groups(P<0.01).3. LSM value and K value, EHBF value was negatively correlated; with the R15 values were positively correlated.4. LSM value with in patients with chronic liver disease CTP grade A, grade B, and grade C in ascending order, were significantly different(P<0.01). The Spearman correlation analysis LSM values were positively correlated with the CTP classification.5. LSM values were positively correlated with ultrasound grading.6. LSM value of patients with chronic liver disease increased sequentially in the order of liver- depression and spleen- deficiency group, liver- kidney yin deficiency group, liver- gallbladder dampness- heat syndrome group; compared with liver- gallbladder dampness- heat group, the LSM value in liver- depression and spleen- deficiency group, liver- kidney yin deficiency group have statistical significance(P<0.05).Conclusion:1. Liver stiffness measurements(LSM) increased with the progress of chronic liver disease.2. Fibro Scan examination has high clinical value in the diagnosis, disease assessment, and risk forecasting of chronic liver disease.3. Dampness-heat toxin is an important factor affecting the value of LSM.