Research On The Relationship Between Plasma Lipoprotein(a) Concentration And Coronary Stenosis After Coronary Angioplasty

Objective To investigate whether there is a correlation between the plasma lipoprotein(a) concentration and coronary stenosis after coronary angioplasty in coronary heart disease patients.Methods A total of 200 cases of "coronary heart disease" patients from 2013 January to 2014 December had prior coronary angiography, and the angiography made again,were enrolled in this study. Comparison of two times before and after the results of coronary angiography, and the patients were divided into two groups according to the results, without the occurrence of coronary stenosis as "control group", and with the occurrence of coronary stenosis as " patients group". Using of "Logistic analysis", "students t-test", "chi square test" and "relative risk" for statistical analysis. Further subgroup analysis in the "patients group", are grouped to lipoprotein a concentration, and the correlation analysis of the severity of coronary stenosis and stenosis parts etc.Results Lipoprotein(a), history of diabetes, gender are relate with coronary stenosis. Lipoprotein(a) concentration is higher, the higher the incidence of coronary stenosis. When plasma lipoprotein(a) concentration is over 213.6mg/L the incidence rate of coronary stenosis is 58.00%;than if lipoprotein(a) plasma concentration is under 53.25 mg/L the the incidence rate of coronary stenosis is 38.00%,which is statistical with P=0.045. Subgroup analysis, lipoprotein(a) is over 213.6mg/L than lower patients "both of stenosis" risk OR=3.488(P=0.019). Lipoprotein(a) is over 213.6mg/L than lower the worthy "significant stenosis" risk OR=2.647(P=0.046).Conclusions Lipoprotein(a) plasma concentrations in patients with coronary heart disease is related to coronary stenosis after coronary angioplasty. And the higher concentration of lipoprotein(a), coronary stenosis occurrence location may be more; the degree of coronary stenosis may be heavier.