| Objective:By observing the influence on survival rate in 1 year,2 years,3 years respe ctively, the median progression free survival time, relief of Specific adverse e vents including musculoskeletal adverse events (MSAEs) and vasomotor sympto ms (VMSs), bone density, and the relationship between specific adverse event s and survival outcome of first-line aromatase inhibitor treatment-related in br east cancer patients with traditional chinese medicine shuganyishen who had th e progressive disease after treatment with a nonsteroidal aromatase inhibitor, h ere is to provide evaluation of traditional chinese medicine shuganyishen.Methods:According to the application of traditional Chinese medicine,143 cases of postmenopausal breast cancer patients of letrozole or anastrozole resistance were divided into two groups, of which 79 cases treated with integrated chinese medicine and exemestane and 59 cases by the latter alone respectively.Other treatment groups were referring to Western standards NCCN treatment guidelines. The end point was time to progress, specific adverse events.Results:1 Comparison of effectiveness1.1 rate of survivalRate of survival in one year of Chinese and Western medicine combined group:94.7%, 91.5% in pure Western medicine group, there is no statistical significance between the two groups (p>0.05)Rate of survival in two year of Chinese and Western medicine combined group: 88.2%,81.4% in pure Western medicine group,here is no statistical significance between the two groups (p>0.05)Rate of survival in three year of Chinese and Western medicine combined group: 82.9%,67.8% in pure Western medicine group, there is statistical significance between the two groups (p<0.05)1.2 survival timeMedian PFS of Chinese and Western medicine combined group was 9.0 months,7.0 months in the control group, P<0.05, the difference was statistically significant.2 Specific adverse events2.1 Musculoskeletal adverse events (MSAEs)Joint pain grading index, visual analog scale score, and the existing score befo re and after treatment in pain intensity difference comparison had statistical sig nificance (p<0.05). Before the group after treatment, the joint reduced bone mineral density increased significantly, compare the difference between a signifi cant statistical significance (p<0.01).2.2 Vasomotor symptoms (VMSs)Compared the two groups before treatment, P= 0.93>0.05, the difference was meaningless, comparable. Compared after 12 weeks and 24 weeks, there had s ignificant difference3 Musculoskeletal adverse events (MSAEs) and Vasomotor symptoms (VMSs) were not associated with superior survival outcomes.4 After the traditional Chinese medicine treatment in the combined group, the Karnofsky performance scales of the combination group than the pure Western medicine group (P<0.05), the difference was statistically significant.According to Kurpperman clinical symptom score sheet and statistical analysis showed:the cure rate and overall efficiency of hot flashes, sweating, sexual apathy, insomnia, lassitude, fatigue, musculoskeletal pain, heart palpitations, skin ant line, headaches of the combination group were better than the control group, and there were dramatically significant differences (p<0.01).comparison the overall efficiency of vertigo, there was significant differences (p<0.05),comparison of the cure rate of vertigo, there was no significant difference (p> 0.05);comparison of the cure rate and the overall efficiency of paresthesia and urinary tract infection in both groups, there was no significant difference (p> 0.05).5 Safety evaluationComparison on estradiol:There was no significant difference in the combination group during before and after treatment (p> 0.05).Conclusions:Traditional chinese medicine shuganyishen combined exemestane could improve the 3 year survival rate, prolong the median progression-free survival.Tradition al chinese medicine shuganyishen can effectively improve the MSAEs and VM Ss, also can improve the patients quality of life. |
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