In many of the molecular structure of drugs containing trifluoromethyl will significantly improve molecular physicochemical properties, thus making in molecular insert trifluoro methyl has a good application prospect, so that people have payed more attention to the chemical reaction of the Togni reagent.it is a very good trifluoro methyl radical donor.In this paper, the reaction of two hydrogen naphthalene with Togni reagent as the three fluorine methyl donor and three ring ring ring ring ring opening was discussed in this paper..In this paper we completed the optimization and selection of catalyst, trifluoro methyl source, solvent and temperature, to determine the optimal conditions for the reaction, and universality of substrate for related research, related to synthesis of substrate on the reaction have good tolerance, so we get a series of trifluoro methyl dihydro naphthalene products containing.In addition, we have also carried out the related research on the product derivatization. The oxidation process of two hydrogen naphthalene products of the aromatic structure of the naphthalene ring compounds. Because in this reaction, we have experienced three ring opening and ring opening, and according to the literatures, we have proposed the possible mechanism of free radical reaction.The method for the synthesis of containing trifluoro methyl dihydro naphthalene compounds provides a convenient and effective way, with good functional compatibility, mild reaction conditions, and other advantages, with good application prospect. |