Studies On The Silk Fibroin Hydrogel In Drug Delivery System

Silk fibroin, an excellent biocompatible material, with non-toxic, no stimulation to the skin of the human body, is widely applied in wound dressing, scaffolds, operation sutures, tissue repair, drug delivery and other aspects. Hydrogel is a kind of biological materials with rich-water and three-dimensional network structure, and the special structure provides the motion space of small molecule drugs. And the water between the surface of the skin and the hydrogel also can promote the skin’s hydration. Therefore, silk fibroin hydrogel is a promising material for transdermal drug delivery system(TDDS), which can make full use both of the silk fibroin and the hydrogel.A surfactant, sodium N-lauroylsarcosinate(SNS) was added in the solution of silk fibroin to cut the time used to form the silk fibroin hydrogel and the in vitro release performance of Rhodamine B was studied. By changing the factors, we can see that what affects the transdermal delivery of Rhodamine B most is the silk fibroin content in the silk fibroin hydrogels. The cumulative release rate can be 100% in 100 hours when put the aqueous solution of Rhodamine B only on the surface of the skin. And the cumulative release rate of the Rhodamine B in silk fibroin hydrogel with the concentration at 10 mg/m L could be 98% at 200 hours while with the concentration at 30 mg/m L just be 30% at 200 hours. The effect of the transdermal delivery of Rhodamine B in the silk fibroin hydrogel of SNS at small concentration was not as significant as the content of silk fibroin. The in vitro release performance of lipophilic drug capsaicin was also studied. We can get almost the same transdermal drug delivery conclusion that what affects the transdermal delivery system most in the silk fibroin hydrogels is the silk fibroin content. The SNS and other content in the silk fibroin hydrogel also effect the release performance of the drugs but not as significant as the silk fibroin.