| Background and objectiveTo detect the levels of serum Soluble nuclear factor êB receptor activation factor ligands(s RANKL) in different types of coronary heart disease(CHD) patients, as well as the correlation of serum s RANKL level with high-sensitivity C-reactive protein(hs-CRP), troponin, gamma glutamyl transpeptidase(γ-GGTP) levels, GRACE score and coronary artery Gensini score.MethodsSerum s RANKL levels were detected with ELISA method in the stable angina pectoris(SAP, 27 cases) group, acute coronary syndrome(ACS, 43 cases) group, including unstable angina(UA, 24 cases) and acute myocardial infarction(AMI, 19 cases), and 20 patients without coronary heart disease group(control group), respectively. And then observed the correlation between s RANKL levels and hs-CRP, troponin, γ-GGTP levels, GRACE score and Gensini score.ResultsThere had no statistical significance(P>0.05) among the three groups of patients’ clinical basic data like average age, gender, body mass index, systolic pressure, diastolic pressure, blood fat and creatinine, the results suggested that three groups of patients were comparable. The level of serum s RANKL in patients of ACS group was significantly lower(P< 0.01) than that in the other two groups, among them, the serum s RANKL level in the control group, SAP group and ACS group were 0.38±0.12, 0.25±0.11 and 0.22±0.11 ng/ml, respectively. Subgroup analysis showed that the serum s RANKL level both in AMI group and UA group patients were significantly lower(P<0.05) compared with SAP group and control group, respectively. Levels of serum s RANKL had no significantly difference(P>0.05) between SAP group and control group. The levels of γ-GGTP, c Tn T and hs-CRP in ACS group patients were much higher than that both in the SAP group and control group(P<0.05). The correlation test showed that serum γ-GGTP and c Tn T levels had positive relationship with GRACE score(P<0.05), as well as Gensini score(P<0.05). SRANKL and hs-CRP levels had no significant correlation(P>0.05) with GRACE score and Gensini score. What’s more, serum s RANKL level had no obvious correlation with γ-GGTP, c Tn T, hs-CRP levels(P>0.05).Conclusion1. Compared with control group and SAP group, the serum s RANKL level in ACS group had a significantly decrease.2. The serum γ-GGTP, c Tn T and hs- CRP levels in ACS patients were significantly higher than that in control group and SAP group.3. Serum levels of γ-GGTP and c Tn T had positive correlation with GRACE score and Gensini score, but serum s RANKL and hs-CRP levels had no obvious correlation with GRACE score and Gensini score. All these results suggested that s RANKL joint other serological indexes or GRACE score might be more effective and timely predict risk and prognosis of CHD. |
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