The Effect Of SN-imDC On Allogeneic Rat Renal Allograft Survival Time And Renal Function

【Objective】by observe the survival time 、renal function and pathomorphism Of kidney transplant in allogene mice injection the modified imDC(immature dendritic cell) by Sinomenine.to clear the immunosuppressive action of Sinomenine.provide the evidence for clinical application.【Methods】 Choose the inbred line SD rat as RTRS,the Wistar rat as donator.Wistar�'SD.use randomized block design build animal model.divide the 60 health SD to five groups as random,give the NS、imDC105、imDC106、imDC105-SN、imDC106-SN each group.after 7days do the kidney transplant surgery.on the 7days after the surgery,pick 6 rats each group as random to kill.test the renal function、pathomorphism. Observe the survival time of rest of rats.【Results】 After the surgery that NS group has a high lever of urea nitrogen and creatiinine.the other group all lower than the NS group.imDC10、imDC106 group has no obvious difference.imDC105-SN、imDC106-SN group has no obvious difference.but imDC105、imDC106 group are higher than im DC105-SN、imDC106-SN group’s data.for the survival time:imDC105-SN、imDC106-SN group >imDC105、imDC106 group>NS group.AR pathomorphism:imDC105-SN、imDC106-SN group <imDC105、imDC106 group<NS group.【Conclusion】 imDC can extend the survival time of RTRS、relief AR, and Modified imDC by Snomenine is more effective than imDC.the Modified imDC by Sinomenine can notable extend the survival time of RTRS,improve the pathomorphism,can protect the kidney for AR.