Clinical Study On The Correlation Between Homocysteine And The Syndrome Differentiation Of Traditional Chinese Medicine In Patients With Coronary Heart Disease

Objective: To analyze the correlation between the levels of Hcy, LDL-C, HDL-C,TG, Cho, TBIL, FIB, UA and the syndrome differentiation of Traditional ChineseMedicine in patients with coronary heart disease.We hope it could reveal the underlyingetiology and pathogenesis from the theory of TCM syndromes and guide the preventionand treatment of coronary heart disease.Methods: This study selected74patients with coronary artery disease diagnosed bycoronary angiography and ranging from45to75years old in Cardiology clinics and wardsin Qilu Hospital of Shandong University from November2013to March2014. We added20cases of healthy elderly as a control group and collected diagnostic laboratory indicatorsand analyzed the differences of LDL-C, HDL-C, TG, Cho, TBIL, FIB, UA, Hcy levelsamong the groups to explore the correlation between laboratory indicators and thesyndrome differentiation of Traditional Chinese Medicine in patients with coronary heartdisease.Results:1.74patients with coronary heart disease were employed in this study and dividedinto four groups: cariac blood stasis group (20cases), cariac phlegm stagnation group(19cases)，Qi deficiency and blood stasis group (20cases), Qi-yin deficiency group (17cases).2.Patients with coronary heart disease in Qi-yin deficiency group were older than thepatients in other groups with significant differences (all P＜0.05).3.The BMI of patients with coronary heart disease in cariac phlegm stagnation groupwere higher than the patients in other groups with significant differences (all P＜0.05). 4. The levels of TC, TG, LDL-C, HDL-C in patients with coronary heart disease weredifferent from the healthy control group. The levels of TC, TG and LDL-C in patients withcoronary heart disease were higher than the healthy control group (P＜0.01), but the levelof HDL-C were lower than the control group (P＜0.05). The level of TC in cariacphlegm stagnation group was higher than other groups (all P＜0.05). The level of LDL-Cin Qi-yin deficiency group was lower than the Qi deficiency and blood stasis group(P＜0.05).5. The levels of UA and TBIL in patients with coronary heart disease were differentfrom the healthy control group. The levels of UA in patients with coronary heart diseasewere higher than the healthy control group (P＜0.01), but the level of TBIL were lowerthan the control group (P＜0.05). The level of TBIL in Qi-yin deficiency group waslower than the cariac blood stasis group and cariac phlegm stagnation group(P＜0.05).6. The levels of FIB in patients with coronary heart disease were were higher than thehealthy control group (P＜0.05). The levels of FIB in the cariac blood stasis group washigher than the Qi deficiency and blood stasis group and Qi-yin deficiency group (P＜0.05).7. The levels of DD-i in patients with coronary heart disease were different from thehealthy control group, but the differences were not significant (P＞0.05).8. The levels of Hcy in patients with coronary heart disease were were higher than thehealthy control group (P＜0.01). The levels of Hcy in the cariac blood stasis group andcariac phlegm stagnation group were higher than the Qi deficiency and blood stasis groupand Qi-yin deficiency group (all P＜0.05).The levels of Hcy in the Qi deficiency and blood stasis group was higher than theQi-yin deficiency group (P＜0.05).9. Correlative analysis showed that there was a positive correlation between Hcy andthe levels of TC, TG, LDL-C, UA, FIB, and DD-i.Significant negative correlation wereobserved between the Hcy level and HDL-C.Conclusions: The levels of TC, TG, LDL-C, UA and FIB in CHD patients werehigher than the healthy people in the control group, while the levels of HDL-C and TBILwere lower than the healthy people. The Qi-yin deficiency syndromes were common in theolder patients with coronary heart disease. The cariac phlegm stagnation syndromes were common in the patients with higher body mass index. Phlegm-turbidity and blood-stasiswere closely related with the levels of blood lipid and Hcy, The Hcy levels decreased inthe transition from excessive syndrome to deficiency syndrome.