Changing Of Vascular Endothelial Growth Factor (VEGF) And Hepatocyte Growth Factor(HG) In Serum And Cerebrospinal Fluid (CSF) In Patients With Moyamoya Diseases

ObjectiveMoyamoya Disease is a kind of chronic occlusive cerebrovascular disease withunknown etiology, charactered by progressive stenosis or occlusion at the terminal portionsof the internal carotid artery and anterior or middle cerebri antery with arterial collateralvessels at the base of the brain. The body angiogenesis is regulated and controlde bymultiple cytokines with difference regulatory roles which is divided into two classes:angiogenesis factors and angiogenesis inhibitors. Angiogenesis factors are a kind of proteinor conpounds which can accelerate angiogenesis. By comparing the difference of VEGFand HGF in cerebrospinal fluid and serum of patients with Moyamoya Disease and otherswithout Moyamoya Disease, we can Moyamoya.MethodsChoose24cases of our hospital neurosurgery in patients with Moyamoya Diseasebetween January2013and December2013as experimental group and all the patients arediagnosed by Digital Subtraction Angiography(DSA). Over the same period selected20patients with subarachnoid hemorrhage caused by trauma to the control group and thosepatients are exclude Moyamoya Disease possibility by cerebral MRI and transcranialdoppler ultrasonography TCD examination.All into the line group, all patients with lumbarpuncture to return2ml cerebrospinal fluid specimens, both in the morning on an emptystomach pumping elbow,5ml of venous blood anticoagulant tube after centrifugation file.By adopting the method of ELISA detection of cerebrospinal fluid and serum VEGF andHGF levels.Results1.The amount of VEGF and HGF in cerebrospinal fluid of Moyamoya Disease groupwas significant differences (p <0.05), and was significantly higher than the control group in the expression of Moyamoya Disease group (p <0.05).2.The amount of VEGF and HGF in serum of Moyamoya Disease group wassignificant differences (p <0.05), and was significantly higher than the control group in theexpression of Moyamoya Disease group (p <0.05).ConclusionThe amount of VEGF and HGF in cerebrospinal fluid and serum of MoyamoyaDisease group is higher,which prompt VEGF and HGF play an important role inpromoting new angiogenesis and protect nerve nutrition and is involved inPathophysiologic process of Moyamoya Disease.