The Correlation Analysis Of Serum IgG Antibody Titer In Group O Pregnant Women And Hemolytic Disease Of The Newborn

Objective1. To analyze the relation between the serum IgG antibody titer in group O pregnant women and the incidence rate and severity of hemolytic disease of the newborn (HDN). To investigate the clinical value of the serum IgG antibody titer in predicting and diagnosing HDN.2. To analyze the effect of different factors on the serum IgG antibody titer and the incidence rate of HDN.Methods From January2012to December2013,565group O pregnant women whose husbands with the blood group except O and her infants in our hospital were collected. The clinical data of mothers and infants were collected by studying cases retrospectively, including the mother’s age, history of pregnancy, complications, serum IgG antibody titer, ultrasound examination of the fetus and the infant sex, gestational age, weight, the way of delivery, occurrence of jaundice and HDN, et al. All date were analyzed by SPSS19.0software. The count data were represented by frequency and rate. The relationship between the serum IgG antibody titer in pregnant women and HDN was analyzed by Spearman correlation test. The chi-square test was used to compare the positive rate of two samples. P value less than0.05was considered to be statistically significant.Results1. No matter whether the value of serum IgG antibody titer in group O pregnant women was high or not, the signs of intrauterine hemolysis, such as fetal edema, ascites or pleural effusion, were not found.2. There was significant difference of positive rate of the serum IgG antibody between women who had two or more pregnancies and those who had one pregnancy (X2=5.122, P<0.05). Furthermore, the percentage of serum IgG antibody titer that was more than or equal to1:128of the former was significantly higher than the latter(X2=10.829, P<0.05). For women who had one pregnancy with different age, there was no significant difference of positive rate of the serum IgG antibody between them(P>0.05). No significant difference of positive rate of IgG antibody was found between women with different gestational weeks.3. There was significant difference of the serum IgG antibody titer between women whose infants had haemolysis disease and those that didn’t have haemolysis disease (Z=-4.512, P<0.001). As the IgG antibody titer rised, the incidence rate of HDN increased(X2=29.810, P<0.001).4. No correlation between the serum IgG antibody titer in group O pregnant women and the neonatal jaundice was found (r=0.102, P>0.05). No correlation was found between the serum IgG antibody titer and the neonatal anemia (r=0.002, P>0.05) 5. No significant difference of the incidence rate of HDN was found between the newborn infants who had different gestational age, sex, the way of delivery or blood group (P>0.05).6. There was no significant difference of the incidence rate of HDN between the newborn infants whose mother took the Yin Chen Tang and the control group (P>0.05).Conclusion1. The serum IgG antibody titer in group O pregnant women had certain value in predicting the occurrence of HDN. When mothers were suspected maternal-fetal blood group incompatibility with abnormal pregnancy or more pregnancies, they should enhance the antenatal examination and took relative treatment on time if needed.2. The serum IgG antibody titer in group O pregnant women can’t predict the severity of neonatal hemolysis.3. When mothers with abnormal pregnancy or more pregnancies were suspected maternal-fetal blood group incompatibility, it was recommended to determine blood group immediately in their newborn infants and observed the status of newborn jaundice closely. When the neonatal jaundice progressed quickly, the newborns should be sent to newborn department promptly. Early diagnosis and early treatment were important to good result.4. Taking Yin Chen Tang had no effect on decreasing the serum IgG antibody titer or preventing the occurrence of HDN.