A Study Of The Relevance Between Prenatal Determination Of Antibody Titer And Hemolytic Disease Of The Newborn And The Relevant Intervention Of Chinese Medicine

Objective To investigate the correlation between maternal antibody titer detection and hemolytic disease of the newborn and the prescription of traditional Chinese medicine to detect abnormal prenatal interventions and to observe the preventive effect on hemolytic disease of the newborn.Methods Retrospective analysis of all cases of prenatal detection of antibody titers in the Department of Gynaecology in Xinxiang Central Hospital from January 2012 to October 2013. Random selection of antenatal detection of irregular antibodies screening as negative and the husband of pure ABO blood group incompatibility of pregnant women, a total of 620 cases. Systematic blood group serology detection is conducted for the selected cases and their newborns. using gel microcolumn technique of IgG and ABO blood group antibody titer of anti A or anti B testing of pregnant women; ABO blood type and RH on neonatal (D) setting, serum free antibody determination of red blood cell, direct antiglobulin test and erythrocyte antibody elution to give a correlation analysis of maternal antibody titer of postpartum and hemolytic disease of the newborn. For pregnant women with antibody titer≥ 1:64 are treated with traditional Chinese medicine for prenatal intervention:4 weeks for 1 courses of treatment. Efficacy is in view of the antibody titer results after 3 courses. Effects of prenatal interventions for preventing haemolytic disease of the newborn are evaluated according to the therapeutic effect.Results Statistical analysis showed no correlation (P> 0.05) between ABO blood group incompatibility in pregnant women and prenatal antibody titer distribution in the 620 cases.213 pregnant women were detected with IgG anti A or anti B≥ 1:64 (34.4%) and postnatal diagnosis of hemolytic disease of the newborn were 66 (11.1%). The pregnant women of the O blood type. A blood type and B blood type were respectively 324 cases (52.3%).145 cases (23.4%) and 151 cases (24.3%); the antibody titer≥ 64 were 138 cases (22.3%),54 cases (8.7%),21 cases (3.4%). Accordingly, hemolysis were 38 cases (6.1%), 23 cases (3.7%).5 cases (0.8%).Traditional Chinese medicine was prescribed for intervention for those with Antibody titer≥1:64. After the treatment,26 cure cases (34.7%). 42 markedly effective cases (56.0%),7 invalid cases (9.3%), the total effective rate 90.7%.Conclusion The detection system of blood group serology in pregnant women, and traditional Chinese medicine intervention on the abnormal, can effectively prevent and reduce the hemolytic disease of the newborn, it is worthy of further clinical research.