The Expression Changes And Significance Of Serum Gamma-glutamyltransferase,Glutathione In The Patients With Preeclampsia

Objective:To observe the expression changes and significance of serum gamma-glutamyltransferase, glutathione in patients with preeclampsia in order to explore the correlation between serum gamma-glutamyltransferase (γ-GT), glutathione (GSH) and preeclampsia.Methods:We randomly selected63cases of preeclampsia. Acorrding to the diagnosis of Obstetrics and Gynecology (the seventh edition teaching material published of people’s medical publishing house), patients were divided into two groups, one of them were mild preeclampsia (mPE, n=32), the other were severe preeclampsia (sPE, n=31). There were28normal pregnant women of control group. Fasting blood was drawn to test y-GT, GSH, serum liver and renal function,24-hour proteinuria and blood pressure were measured. GSH level in serum used ELISA method, by automatic biochemical analyzer test serum y-GT level, blood lipid, hepatic and renal function, and24hours urinary protein in order to discuss their roles in the pathogenesis of preeclampsia.Result:1. Three groups of age, pregnant weeks had no significant difference.2. The result of y-GT, GSH in each group:①γ-GT levels in the patients with preeclampsia group was significantly higher than normal pregnancy, GSH content was significantly lower than normal pregnancy group, both had significant difference (P<0.05).②The levels of serum γ-GT in patients with severe preeclampsia was higher than that of mild group, GSH content was lower than the mild group (P<0.05).3. The results of blood lipid compared with each group:①Severe preeclampsia compared with the normal group, the levels of the total cholesterol (CHO), triglycerides (TG), low density lipoprotein (LDL) increased significantly, high-density lipoprotein (HDL) significantly decreased in patients with severe preeclampsia, the difference was statistically significant (P<0.05).②Mild preeclampsia group compared with normal group, the levels of low density lipoprotein (LDL) in the mild group was higher than the normal group, high density lipoprotein (HDL) was lower than normal group (P<0.05), total cholesterol (CHO), triglycerides (TG) and normal group had no significant difference (P>0.05).③The severe preeclampsia group compared with the mild group, the levels of total cholesterol (CHO), triglycerides (TG), low density lipoprotein (LDL) in the severe preeclampsia group were higher than in mild group, high density lipoprotein (HDL) was lower than the mild group (P<0.05).4. By Pearson correlation analyses, y-GT was positively correlated with systolic blood pressure, diastolic blood pressure, alanine transaminase, aspartate transaminase, total cholesterol, low density lipoprotein cholesterol, serum uric acid,24-hour proteinuria (P<0.01), and negatively correlated with high density lipoprotein cholesterol and GSH (P<0.01).Conclusion:Expression of y-GT was significantly higher in patients with preeclampsia and expression of GSH was significantly lower in patients with preeclampsia. Both of them were positively correlated with blood pressure and can predict the severe of preeclampsia.