The Clinical Curative Effect Of Acupuncture For Migraine At Acupoints On Involved Meridian And Its Impact On Plasma Beta-endorphin

Objective:This study is aimed to observe the clinical curative effect of acupuncture treatment of migraine without aura and its influence on plasma beta-endorphin (β-EP), so as to provide some certain scientific basis for acupuncture treatment of migraine.Methods:1.48migraine patients without aura and40healthy subjects were enrolled in this study. Healthy subjects had no acupuncture treatment.48migraine patients were randomly divided into three groups:the treatment group1(Group A), treated with Qiuxu (GB40), Waignan (TE5) and Yanglingquan (GB34) bilaterally on the Shaoyang meridian; the treatment group2(Group B), treated with Pianli (LI6), Chongyang (ST42) and Zusanli (ST36) bilaterally on the Yangming meridian and the control group (group C), treated with sham acupuncture on3non-acupoints bilaterally. Three acupuncture groups received one treatment per day, five times for a treatment course, two days off between courses, four treatment courses in total. The VAS score, MSQ score, SAS score and SDS score of three groups before and after four courses of acupuncture treatment were recorded in detail respectively.2. With the Enzyme-linked immunoassay (ELISA) technology, the plasma β-EP was selected as the blood biochemical index, and the level of the plasmaβ-EP in healthy subjects and migraine patients before and after treatments was detected to study the influence of the plasma β-EP treated on different acupoints with acupuncture treatment of migraine.Results:1. The clinical curative effect of acupuncture for migraine patients without aura.(1) The baseline of three groups showed no statistical differences (P>0.05).(2) After four courses of acupuncture treatment, the VAS score, the MSQ-function limitation score and the MSQ-dysfunction score before and after acupuncture treatments in group A showed significant statistical significance (P＜0.01); the MSQ-emotion score, the SAS score and the SDS score before and after acupuncture treatments in group A showed statistical significance (P＜0.05); the VAS score, the MSQ-function limitation score and the MSQ-dysfunction score before and after acupuncture treatments in group B showed significant statistical significance (P＜0.01); the MSQ-emotion score and the SDS score before and after acupuncture treatments in group B showed statistical significance (P＜0.05); the VAS score before and after acupuncture treatments in group C showed significant statistical significance (P＜0.01); the MSQ-function limitation score before and after treatments in group C showed statistical significance (P<0.05).(3) After four courses of acupuncture treatment, the VAS score, the MSQ-function limitation score, the MSQ-dysfunction score, the SAS score and the SDS score between group A and group B showed statistical significance (P<0.05); the VAS score and the MSQ-function limitation score between group A and group C showed significant statistical significance (P<0.01); the MSQ-dysfunction score, the MSQ-emotion score, the SAS score and the SDS score between group A and group C showed statistical significance (P＜0.05).(4) After four courses of acupuncture treatment, Group A was better than group B in the VAS score improvement value (P＜0.05), and significantly better than group C (P＜0.01). The MSQ-function limitation score improvement value and the SAS score improvement value between group A and group C showed statistical significance (P＜0.05).2. The evaluation of plasma β-EP level before and after acupuncture treatments.(1) The baseline of the plasma β-EP level in migraine patients without aura and healthy subjects showed no statistical differences (P>0.05). Compared with the healthy subjects, the level of plasma β-EP in migraine patients was significantly reduced (P＜0.01).(2) After four courses of acupuncture treatment, the level of plasma β-EP before and after acupuncture treatments in three groups showed significant statistical significance respectively (P＜0.01); the plasma β-EP level between group A and group B showed statistical significance (P＜0.05); the plasma β-EP level between group A and group C showed statistical significance(P<0.05); the improvement value of plasma β-EP level between group A and group C showed statistical significance (P<0.05).3. The correlation between the variation of plasma β-EP level and the variation of clinical curative effect of acupuncture for migraine without aura.After four courses of acupuncture treatment, the VAS score improvement value and the improvement value of plasma β-EP level in group A showed significant positive correlation (r=0.573, P=0.026); the improvement value of the MSQ-function limitation score and the improvement value of plasma β-EP level in group A showed significant positive correlation (r=0.536. P=0.039); the VAS score improvement value and the improvement value of plasma β-EP level in group B showed significant positive correlation (r=0.555, P=0.032).Conclusions:1. The clinical curative effect of acupuncture for MO on involved meridian is significant. Acupuncture for MO on involved meridian can obviously alleviate the headache strength, improve the quality of life and improve the state of anxiety than acupuncture on non-involved meridian and non-acupoints.2. Acupuncture for MO on different acupoints all can significantly increase the level of plasma β-EP in migraine patients with the abnormal reduced level of plasma β-EP before acupuncture treatments. Acupuncture for MO on involved meridian can obviously improve the level of plasma β-EP than acupuncture on non-acupoints.