Determination Of Antioxidant Capacity On The Clinical Significance Of Patients With Rheumatoid Arthritis And Relationship To Disease Activity

Objective:To measure the levels of antioxidant markers total antioxidant status(TAS) andsuperoxide dismutase(SOD) in serum, and analyze the correlation between the levels of themand clinical or laboratory indicators in rheumatoid arthritis(RA). To explore its role ofantioxidant capacity in the RApathogenesis and disease progression.Method:91patients with RA were diagnosed in the First Hospital of Jilin University as the casegroup between March2013and December2014. All of the patients, according to the DAS28scores, were divided into two groups: Values DAS28≤3.2means low-diseaseactivity(38cases), and values DAS28>3.2means moderate and high-disease activity(53cases).Recorded clinical indicators of duration of illness, morning stiffiness time, TJC, SJC, DAS28,and related laboratory indicators, such as WBC, RBC, PLT, ESR, CRP, RF, anti-CCP. And70healthy individuals were collected from physical examination center of the First Hospital ofJilin University as the healthy control group. Recorded laboratory indicators, such as WBC,RBC, PLT, ESR, CRP, RF, anti-CCP. To compare the difference of TAS and SOD levels inserum between these groups and analyze its correlation with these clinical and laboratoryindicators in RA. The statistical analysis was performed with SPSS17.0for Windows.Results:1.The serum levels of SOD and TAS in RA were significantly lower than those of thehealthy control group, the levels of ESR, CRP, RF, and Anti-CCP were remarkably higherthan those of the healthy control group(P<0.05).2.The serum levels of TAS, SOD, RBC in moderate and high-disease activity group ofRA were significantly lower than those of the low-disease activity group and healthy controlgroup, and WBC, PLT, ESR, CRP, RF and Anti-CCP were remarkably higher than those ofthem, and the morning stiffiness time,TJC,SJC and DAS28were significantly higher thanthose of low-disease activity group(P<0.05); the levels of TAS, SOD in low-disease activitygroup were remarkably lower than those of the healthy control group, and WBC, PLT, ESR, CRP, RF and Anti-CCP were remarkably higher than those of the healthy controlgroup(P<0.05).3.The serum levels of TAS in RA patients was significantly negatively correlated withRF, TJC, SJC, CRP, ESR, DAS28(P<0.05), but no correlation was found between TAS andWBC,Anti-CCP(P>0.05).4.The serum level of SOD in RA patients was remarkably negatively correlated with RF,TJC, SJC, CRP, ESR, DAS28(P<0.05), but no correlation was found between SOD andWBC,Anti-CCP(P>0.05).5.The serum level of TAS and SOD in RA patients were correlated withTAS(r=0.81,P<0.05).Conclusions:1.Oxidative stress was involved in the pathogenic process of RA.2.Antioxidant capacity in patients with RA was lower and the markers of antioxidantcapacity TAS and SOD can be used for the auxiliary diagnosis and clinical observation of RA.3.The levels of TAS, SOD were associated with RA disease activity and they may be themarkers in evaluating clinical disease activity of RA.4.It suggests that the markers of antioxidant capacity TAS and SOD may be useful inevaluating the progression of RA as well as in elucidating the mechanisms of diseasepathogenesis.