The Study Of Epidemiological Features And Risk Factors Of Hand-foot-mouth Disease In Urumqi City

Objective：To analyze the epidemiological features of Hand,foot and mouth disease(HFMD) in Urumqi city from2009to2013,To study the etiological proportion ofHFMD，To explore the risk factors of HFMD in Urumqi city and provide scientific basisfor prevention and control measures.Methods： From“national disease surveillanceinformation reporting system” collected the incidence information in Urumqi city from2009to2013， descriptive epidemiological approaches were used to analyze thedistribution of HFMD,collect the stoll、throat and saliva specimens of HFMD used tolaboratory etiologic test. The survey of HFMD risk factors using case-control study, From“national disease surveillance information reporting system”selected clinical diagnosis orlaboratory diagnosis HFMD cases154as Case group,and selected323Healthy children nowith HFMD as control,a unified questionnaire was used to survey,statistical analyses wereconducted with SPSS13.0.Results:1. A total of11126cases reported in Urumqi city from2009to2013,the average annual incidence rate of HFMD are75.89per10000, repoted2death cases,34severe case and17emergencies of HFMD infectious.there is HFMD casesreported all the years,the peak period of incidence of HFMD in June to July,the incidencerate of central urban area higher then urban districts.The sex ratio between male andfemale are1.52:1,the male cases are more than famale.Children under5year old is majorwho suffering from HFMD, Occupational distribution showed cases concentrated inScattered children and nursery children.2.from2009to2013total of2061specimenswere tested,1699samples were found positive and the positive rate was82.43%. Theconstituent ratio of EV71，CoxA16and other enterovirus in the positive sampel are32.84%、44.61and22.54%,in the five years the proportion of,EV71，CoxA16and otherenterovirus are inconsis（tP〈0.001）.3. The result of case-control study showed that poorsanitation（OR=2.321,95%CI:1.659～3.246）, mixed feeding（OR=2.725,95%CI:1.154～ 6.453）,suffered from underlying disease（OR=5.172,95%CI:2.134～12.540）, often bitefingers（OR=2.303,95%CI:1.699～3.122）,exposed to public place nearly10days（OR=2.629,95%CI:1.537～4.499）,exposed to HFMD within10day（sOR=62.819，95%CI：7.449～529.795）were independent risk factors, The kindergarten or community withpatients （OR=0.415,95%CI:0.241～0.714）,female （OR=0.552,95%CI:0.336～0.906）,older than three （OR=0.503,95%CI:0.275～0.921） were protectivefactors.Conclusion: The incidence rate of HFMD have a regional difference in Urumqifrom2009to2013; the proportion of main pathogens HFMD have changed;Indirectcontacts were the main risk factors of HFMD in Urumqi city, To reduce public exposure,form good sanitary habits,Strengthens the health education were An effective way toprevention and control of HFMD.