Pharmaceutical Research Of Vinegar Rhizoma Zedoariae Formula Particles

Granules based on traditional Chinese medicine theory, while retaining the original medicinal active ingredients on the use of modern preparation techniques to save herbs, improve efficiency and save energy at the core goal of the new Pieces. In this thesis, but the principle of constant strain on the preparation process, quality standards vinegar Curcuma Granules were (including fingerprints) and preliminary stability study to explore alternative Granules vinegar vinegar Curcuma Curcuma Pieces scientific, feasibility and analysis of possible problems, as vinegar Curcuma granules provide a scientific basis to expand the clinical application.Process of preparing granular vinegar Curcuma formula:A multi-index comprehensive study, through experimental research, established the process parameters vinegar Curcuma recipes particles. The optimum process conditions to take vinegar Curcuma Pieces, adding six times the amount of water, soak0.5h, steam distillation extraction6h, collecting volatile oil, liquid filtration, selector save, eight times the amount of residue added to water, extracted1h, filtration, combined decoction above, use12000r/min speed centrifugation, concentrated to clear paste the relative density of1.10(60℃) of liquid, spray drying to obtain a dry extract powder. Take vinegar Volatile oil, according to β-cyclodextrin:volatile oil=8:1mixing ratio,40times the amount of water, a saturated aqueous solution method ultrasonic20min X3(60℃, the frequency of20KHz, power250W), removed, placed in the refrigerator24h, filtration,40℃low temperature drying3h, spare; take dry extract powder, adding β-cyclodextrin inclusion, after mixing, spray drying granulation drying, spare.Particulate quality standard of vinegar Curcuma formula, established a vinegar Curcuma control medicine and curdione, curcumol, germacrone, Curcuma glycol is controlled by TLC identification method using high performance liquid chromatography, the establishment of curcumin (C21H20O6) method for the determination and methodological research, develop curcumin content of not less than0.04mg/g; vinegar Curcuma granules fingerprints were studied by different manufacturers or batches of10groups of vinegar made from Curcuma granules fingerprint similarity were above0.9. There are established patterns vinegar Curcuma Granules, improve the vinegar Curcuma Granules quality standards.Three different batches of samples for preliminary stability study, the results showed that vinegar Curcuma Granules within six months of good stability.The test results showed that:vinegar Curcuma recipe preparation particles scientific and feasible, better quality standards, Granules good stability, and easy to adjust, carrying and storage. The results for the establishment of vinegar Curcuma Granules quality standards provide a scientific reference.