Analysis Of Persistent Protective Effect Of Hepatitis B Vaccine Among The Children Under5Years Old In Suzhou

Objectives: To evaluate persistent immune effect of hepatitis B vaccine, and toexamine the feasibility of booster program of hepatitis B vaccine among the children under5years old in Suzhou.So as to provide scientific basis for improving of the hepatitis Bimmune program for children in Suzhou city.Methods：（1）Sampling Method： Multi-stage random cluster sampling was used inthe cross-sectional study. First,6districts (cities) were taken from the12districts (cities) ofSuzhou at random. Then2towns (streets) of the sampling district (city) were chosen. Atlast,25healthy children from0~,1~2,3~4years old group were selected in each town(street). A total of900children and their parents were selected as the research sample.（2）Survey Method： A questionnaire survey was conducted among the selected children’sparents and guardians, and the vaccination certificate was examined. Investigations wereconducted on the information including hepatitis B vaccine immunization history, eachchild’s age, gender, region, times of immunization, first timely vaccination and full timelyvaccination.1～3ml finger or venous blood was collected to examine the related index（.3）Examining Method： The serum was segmented in time and was kept in the refrigeratorunder-20℃to examine related index. ELISA was used to inspect5serological markers ofhepatitis B virus. Chemiluminescent microparticle immunoassay was used to detectHepatitis B surface antibody (HBsAb) concentration（.4）Statistical Method：All data wereinput into the EXCEL to establish a database and SPSS19.0was used to make statisticalanalysis.Results：（1）Hepatitis B vaccine inoculation：Full course vaccination rate is93.16%,and the vaccination rate is significantly different between the age groups.(2)Distribution ofhepatitis B serological markers：The positive rates of HBsAg, HBsAb, HBeAg, HBeAband HBcAb are0.11%,74.54%,0%,2.17%and1.25%respectively. Significant differenceexists among different age groups with HBsAb positive rate. The positive rate of HBsAb decreases with the increase in age. Single factor analysis showed that the positive rate ofHBsAb is correlated with age, immune times and timeliness of full course inoculation.(3)Hepatitis B vaccine immune response：The geometric mean concentration of HBsAb is38.29mIU/ml, and its level is mainly influenced by age and inoculation duration（P＜0.05）.Immune response was76.24%after Hepatitis B vaccine immunization. Significantdifference was shown among different interval time of vaccination immunity response（P＜0.01）.Conclusion： The high inoculation rate of hepatitis B vaccine among children under5years old proved that the immunization program of hepatitis B vaccine for children hasbeen well implemented in Suzhou. The immune effect of hepatitis B vaccine is weakenedwith the increase in age In addition, the level of the geometric mean concentration ofHBsAb was low in the group of children from3to4years old. It is suggested that thehepatitis B vaccine immunization be strengthened for children aged3to4years.