Omega-3Polyunsaturated Fatty Acids Prevent Progression Of Liver Fibrosis And Promote Liver Regeneration After Partial Hepatectomy In Cirrhotic Rats

Objective:To evaluate the effect of omega-3polyunsaturated fatty acids (ω-3PUFA) on liver regeneration after hepatectomy and antifibrosis under conditions of liver cirrhosis in rats.Methods:Omega-3polyunsaturated fatty acids were intravenously injected in n-3PUFA group3days before operation to1day after partial hepatectomy. Seventy precent hepatectomy was carried out in rats,which were subsequently divided into4groups:(1)normal and hepatectomy group(PH),(2)liver cirrhosis and hepatectomy group(LC+PH),(3)liver cirrhosis, n-3PUFA (1ml/kg) and hepatectomy group (LC+n-3PUFA+PH),(4) liver cirrhosis, n-3PUFA (2ml/kg) and hepatectomy group (LC+n-3PUFA*+PH). Body/liver weight ratios,Serum parameters, histopathological examination, immunostaining and quantification of mRNA expression were also investigated.Results:Liver regeneration was significantly delayed compared with PH group7days after hepatectomy(PH) in LC+PH group. On the other hand,liver regeneration of LC+n-3PUFA*+PH group increased significantly compared with LC+PH group7days after PH. In LC+PH group,liver cirrhotic was significantly higher compared with LC+n-3PUFA+PH group7days after PH.Meanwhile,liver cirrhosis of LC+n-3PUFA*+PH group was significantly reduced compared with LC+n-3PUFA+PH group7days after PH.Conclusions:These results clearly show n-3PUFA that reduce liver fibrosis and promote liver regeneration, even under cirrhotic conditions.