The Study Of Preparation And Property Of HAPw/nmCaO Bone Repair Materials

[Objective] Studing the process conditions of preparing calcium nano oxide (CaO), and exploring the process parameters of modifying hydroxyapatite whisker (HAPw) and the process conditions of preparing porous via sol-gel process, which had prepared HAPw/nmCaO porous bone repair material; at last researching on the in vitro degradation properties of HAPw/nmCaO porous bone repair material.[Materials and Methods] ①uring the preparing nanometer CaO via sol-gel process,the dispersion and diameter of CaO were discussed with different dosage of PEG6000 and pH value;②The HAPw were modified by sol-gel process,and thermally fused to form HAPw/nmCaO compound,which were examined by transmission electron microscope,scanning electron microscope and energe dispersive X-ray spectroscopy;Probing into the morophlogies of CaO changed in different dosage of PEG6000 and pH value;③study the effect of different proportions of CaO and HAPw on granular composite material porosity and compressive strength;studing the effect of different proportions of PMMA and precursor complexes on the porous composite material porosity and compressive strength;studing the effect of different sintering the temperature and incubation time on porous composite compressive strength; the porous HAPw/nmCaO composite, observed in the limiting case of the degradation performance; ④ observing the in vitro degradation properties of the porous HAPw/nmCaO composite bone repair material which in citric acid buffer solution.[Result] The diepersion and diameter of nano CaO were perfectly via sol-gel at mPEG:m calcium nitrate=1:2、pH=8.5; when pH=6.2, mPEG:mcalcium nitrate=1:2, temperature 70 C, the melting surface of whisker with many uniformly dispersed nano particle CaO; Along with reducing of the ratio of CaO and HAPw, the compressive strength of the material increased firstly and then decreased, at the ratio of CaO and HAPw was 1:2, the compressive strength of 1.0176MPa which is the maximum; with increasing of the ratio of PMMA and precursor compound,the porosity of composite porous artificial bone increased,but the compressive strength decreased; when the sintering temperature was constant, with the prolongation of holding temperature time, the compressive strength of the composite porous artificial bone increased firstly and then decreased; when holding temperature time was constant, the compressive strength of porous material increased firstly and then decreased with increasing of sintering temperature; the optimal sintering condition of compressive strength is at 750 ℃ and 2 hours holding, its compressive strength is 0.6430MPa;the porous HAPw/nmCaO composite materials and the porous HAPw immersed in citrate buffer after 120 hours degradation rate respectively were 39.75% and 22.11%.[Conclusion] nanometer CaO was prepared by sol-gel method with Calcium nitrate; with the different pH value, temperature and the amount of PEG6000、HAPw/nmCaO formed different morphologies;using CaO viscous, can prepare particulate HAPw/nmCaO composites; the expect of different ratio between CaO and HAPw on the granular composite material porosity and compressive strength was different; the different ratio of PMMA and precursor complexes, have different effects on the particle porosity and compressive strength; sintering temperature and holding temperature time have both influenced the compressive strength of materials; in a citrate buffer after immersing, the porous HAPw/nmCaO and the porous HAPw can be dedradated.