Clinical Research Of Danhong Injection In Patients With Yueyu Zheng Of Acute Cerebral Infarction

Objective:By observing the extent of 80 cases of acute cerebral infarction nerve function impairment(NIHSS score), basic daily living scale score(Barthel index), TCM syndromes individual score and three months after the modified Rankin Scale score and so on, to assess the treatment of acute cerebral infarction Danhong injection blood stasis clinical efficacy syndrome. Methed:1.Collecting 80 cases of acute cerebral infarction patients in the department of internal neurology of Hubei Province Chinese Medicine Hospital,department of Neurology in Hubei Provincial People’s Hospital and Zhongnan Hospital of Wuhan University from January 2013 to December 2014.To detail the basic information and the medical history of all the patients,which were diagnosed with blood statis syndrome of stoke in Meridian.2.80 cases of patients with acute cerebral infarction were divided into two groups:the control group and the observation group.Two groups were given a regular basis symptomatic treatment and then the observation group was given 20 ml of Danhong injection which was combined with 0.9% sodium chloride solution 250 ml by intravenous drip path to patients once a day; but the control group received a 20 ml of 0.9% sodium chloride which was combined with 0.9% sodium chloride solution 250 ml by intravenous drip path to patients once a day.Course of the treatment was 14 days and observation for 3 months was to evaluate the clinical effects. Clinical evaluation indicators included NIHSS score, Barthel Index score of TCM syndrome and 3-month mRS score. During the research,we had to calculate and record NIHSS score, Barthel index before and after treatment, and also TCM syndrome indicators.At last,only we did compare the clinical results from the two groups to get the treatment efficacy.By the way, through recording the data with before and after treatment of laboratory parameters such as blood, urine, feces three conventional, liver and kidney function, blood clotting and other conventional, which are compared with each other to ensure the safety of Danhong injection.3.Statistical analysis was performed by using statistical software SPSS17.0. Count data was used by Chi-square test(χ2 test), and measurement data using t test or rank sum test to statistical data. Observation:1.There was no significant difference between the two groups in the general information of gender,age,comorbidities,past medicine history,and so on,P>0.05.So it had no statistically significance between the two groups.2.NIHSS scores and Barthel index:Acoording to the results of NIHSS score, Barthel index before and after treatment,we compared the results of the two groups before and after treatment,P<0.05.It was found that neurological deficit and living skills get beter after the 14 days of treament.Compare with the datas of the two groups,P<0.01,which was cerfied that Danhong injection could improve the neurological deficit and the basic activities of daily living.3.Among the TCM clinical improvement of symptoms, there were 3 cases of the clinical cure, 17 cases of significant effect, effective in 14 cases of general effect and 6 cases of no effect.The total efficiency of the observation group was up to 85.00%.While in the control group, there were 2 cases of the clinical cure, 9 cases of significant effect,effective in 18 cases of general effect and 11 cases of no effect.Also the total efficiency of this group was only 72.50%. After the Ridit analysis, the results of TCM clinical improvement of symptoms showed that Danhong injection could reduce the TCM symptom scores, and then improved the clinical symptoms of acute cerebral infarction.4.By comparing the individual symptom scores of TCM, both of the two groups of the individual symptoms were improved.It prompted that the observation group improve TCM symptom more than the control group,such ashemiplegia, partial body numbness, headaches or limb pain, dark red or dark purple lips, dull red and tongue with petechiae(P<0.05).And it indicated that Danhong injection therapy stasis syndrome had a significant effect, which gave full play to its role of blood circulation.5.Three months after the modified Rankin Scale score:There was losing 7 cases of patients in follow-up period.According to the evaluation criteria,there were 23 cases of patients mRS≤1 in the observation group, accounting for 62.5%; but mRS>1 of patients had 14 cases, accounting for 37.84%.While there were 13 cases of patients m RS≤1 in the control group,accounting for 37.14%;but m RS>1 of patients had 22 cases, accounting for 68.82%.Using t test, P<0.05, there were diferences.It suggested that neurological recovery in patients in the observation group was beter than the control group.6.Drug safety observation: By comparing the laboratory values of liver and kidney function and blood coagulation conventional key indicators before and after treatment, there was no obvious abnormalities in the treatment process,and and serious adverse reactions such as gastrointestinal bleeding did not appear in the course of medication. Results:From the perspective of the Chinese medical to understand the acute cerebral infarction, blood stasis was not only a pathological product but also a risk factor, and it appeared erery time of the disease or throughout the course of the disease.Danhong injection had blood circulation effect, and improved brain microcirculation and the clinical symptoms effectively,then reduced the patiengts with neurological deficits and improved the daily lives of patients basic life activity, thereby reduced morbidity, short-term changes in patient prognosis.In the clinical application, there were fewer adverse reactions by being given Danhong injection,which was another important advantage,and it was worth of promotion in the clinical application.However, it still has some problems in the clinical study. Obviously,the time of the clinic observation is too short to observe the patients of acute cerebral infraction in the long-term situation, we need to set the follow-up and the follow-up observations in order to observe the long-term effect of the drug after the intervention.