The Treatment Efficacy Of Tongxinluo And Statins In The Patients With Carotid Atherosclerotic Plaque :A Meta-analysis

Objective To investigate the treatment efficacy of Tongxinluo compared with statins in patients with carotid atherosclerotic plaques.Methods We systematic and exhaustive retrieved the Chinese and foreign language databases from their establishment date to December of 2014 to collect the randomized, controlled and clinical trials about the treatment efficacy of Tongxinluo compared with statins in patients with carotid atherosclerotic plaques, and then the RevMan5.2 soft ware was used for Meta analyses.Results A total of 23 randomized controlled trials were included, involving 2355 patients and mean duration of 20±7.47 weeks. The results of Meta analyses showed that, the single use of Tongxinluo and statins in improving carotid artery intima-media thicknes(IMT) and blood lipid levels had no significant difference(MD-0.06;95%CI-0.17-0.05;P=0.26 and MD 0.19;95%CI-0.00-0.38;P=0.05).But the single use of Tongxinluo had more advantages than statins in improving triglyceride(TG)level(MD-0.28;95%CI-0.44--0.11; P=0.001). Tongxinluo combined with statins had more advantages than single using statins in the improvement of patients with IMT, plaque area, plaque score, blood lipid level and CRP(P<0.01). However, as to evaluate the adverse reactions, Tongxinluo had less percentage than statins(OR 0.44;95%CI 0.27-0.73;P=0.001).Conclusion In the treatment of patients with carotid atherosclerotic plaques, Tongxinluo combined with statins is the best therapeutic scheme in our study.