| Objective:To explore the clinical efficacy and safety of traditional Chinese medi cine(Xiao Huoluo Dan) treatment of thalamic pain in the recovery stage of ischemia stroke, so evidence and thinking based medicine can be provided for the application of clinical treatment on this diease.Methods: This study on the system summary of Chinese and western medicine treatment of thalamic pain in the recovery stage of ischemia stroke, on the basis of using the random number table method, according to the same inclusion and exclusio n criteria, in the first affiliated hospital of henan institute of traditional Chinese ence phalopathy hospital outpatient and ward of 64 patients with thalamic pain in the reco very stage of ischemia stroke as the research object, randomly divided the patients in to two groups, 32 cases in the treatment group was treated with Xiao Huoluo Dan c ombined with carbamazepine, control group 32 cases only with carbamazepine therapy.Evaluated the pain degree of change by using the visual analogue scale method(visual analogue scale, VAS) dynamic monitoring. Two sets were observed for four weeks, a nd in the before and after treatment used the changes of VAS score to understand th e change of the patients and observed the improvement of TCM syndrome as well a s the safety index and the incidence of adverse events/reaction, etc.Result: Before the treatment,the baseline data of two groups such as compariso n in cases of gender, age distribution, and course of disease, accompanied with othe r diseases showed no significant differences(P>0.05), conform to the requirements of the medical statistics, analysis of the results from 4 aspects as follows:1. Clinical efficacy analysis of total: The total effective rate in the treatment gro up was was 78.1%, while the control group was 62.5%, the total clinical curative effect is better than that of control group, the difference of the total effective rate betw een two groups was statistically significant(p<0.05). Prompt Xiao Huoluo Dan had de finite clinical effect of thalamic pain in the recovery stage of ischemia stroke.2. VAS scale score: Before the treatment, the comparison between two groups was comparable(p>0.05); Two groups before and after treatment were compared wi thin the group, The treatment group after statistics processing was statistically signific ant(p<0.01), the control group after statistics processing was statistically significant(p<0.05), all have significant differences, both groups can improve patients’ pain sym ptoms; comparison between the two way after treatment, the treatment group was bet ter than that of control group(p<0.05), there were significant differences, suggesting Xiao Huoluo Dan can effectively reduce VAS scale score values.3. TCM syndrome integral comparison: Before the treatment,the comparison betw een two groups was comparable(p>0.05); treatment group before and after treatment in comparison,the curative efficacy was significantly(p<0.01), the control group in co mparison before and after treatment group had no statistical significance(p>0.05); the contrast between the two groups after treatment was statistically significant(p<0.01),indicating Xiao Huoluo Dan can obviously improve cold phlegm and blood stasis re sistance syndrome.4.There was no serious adverse reactions between treatment group and control gr oup during treatment.Conclusion:Traditional Chinese medicine(Xiao Huoluo Dan) can improve the clinical symptoms in patients with thalamic pain in the recovery stage of ischemia stroke and cold phlegm and blood stasis resistance syndrome.It was safe and effective, worthy of popularization and application in clinic. |
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