Research On The Influence Of Metabolic Syndrome On Cardiac Diastolic Function In The Elderly

Objective:The purpose of the study is to investigate the influence of metabolicsyndrome on cardiac diastolic function in the elderly.Method:Selete222patients who were hospitalized in the Department ofCardiology and the Department of Gerontology of the First Hospital ofJilin University from January1，2014to December31,2014, age≥60years, color doppler ultrasound measurement of left ventricular ejectionfraction (LVEF) revealed55%or higher.All those patients suffered one ormore from hypertension，diabetes mellitus，lipid disorders，obesity andany other common diseases in the eldly. According to the E/e ’ levelsmeasured by color doppler ultrasound,included patients were divided intodiastolic dysfunction group and normal diastolic function group.Patientswithout history of type2diabetes were divided into normal fastingplasma glucose group and impaired fasting glucose group,choosing thefasting plasma glucose level of6.1mmol/L as the boundry line.Collectclinical data, laboratory examination indexes and the results ofechocardiogram so as to investigate the influence of metabolic syndromeon cardiac diastolic function in the elderly by statistical analysis.Results:1.Body mass index, age, BNP levels, triglyceride levels, fastingblood glucose levels in diastolic dysfunction group were higher than thatin normal diastolic function group, the difference was statisticallysignificant(P<0.05).2.Compared with normal diastolic function group,therate of patients diagnosed with hypertension and diabetes were higher indiastolic dysfunction group,the difference was statistically significant(P<0.05).3.In diastolic dysfunction group,the correlationanalysis between age, body mass index, fasting blood glucose levels,triglyceride levels and BNP levels were positive,the correlationcoefficient were（r=0.628，P <0.001），（r=0.425，P <0.001），（r=0.155，P=0.043），（r=0.438，P <0.001）respectively.4. In diastolic dysfunctiongroup,the correlation analysis between age, body mass index, fastingblood glucose levels, triglyceride levels and E/A were negative,thecorrelation coefficient were （r=-0.159，P=0.039），（r=-0.327，P<0.001），（r=-0.163，P=0.034），（r=-0.166，P=0.031）respectively.5.Thecardiac diastolic function in normal fasting plasma glucose group wasbetter than that in impaired fasting glucose group, the difference wasstatistically significant （P<0.05）.6. Multivariate logistic regressionanalysis revealed that age, body mass index, fasting blood glucose levelswere independent risk factor for diastolic cardiac dysfunction in theelderly.Conclusion:1.Cardiac diastolic function in the elderly is relevant with age, bodymass index, BNP levels, triglyceride levels, fasting blood glucoselevels.2.Elderly patients with hypertension or diabetes are more likely tosuffer from cardiac diastolic function.3.With the improvement of age,body mass index, triglyceride levels and fasting blood glucose levels,cardiac diastolic function decreases in the eldly.4.Compared with normalfasting plasma glucose group，patients in impaired fasting glucose groupare more likely to suffer from cardiac diastolic dysfunction.5.Afteradjusting for other factors,multivariate logistic regression analysisrevealed that age,body mass index, fasting blood glucose levels areindependent risk factor for cardiac diastolic dysfunction.