The Clinical Observation Of Humoshengji Powder Combined With Proton-pump Inhibitor Drugs On The Treatment Of Peptic Ulcer

Objective:Observation Humoshengji powder and proton pump inhibitors in the treatment of peptic ulcer healing, and from theory and clinical study of two opposite system to study the effect of coating raw muscle bulk mechanism.Methods:Choice in January 2013-July 2013 in our hospital outpatient treatment of 59 cases of peptic ulcer of digestive diseases, all cases in our hospital diagnosed as peptic ulcer, according to the order to the patient were randomly divided into observation group and control group, observation group and control group,30 cases in the control group of 29 cases. The control group patients give panxi tora azole 40 mg static drop BID for 10 days, after the change of rabeprazole azole 10 mg BID oral six weeks. Observation group in the control group on the basis of given Humoshengji powder treatment, the production of schisandra fruit powder, notoginseng powder, bletilla powder, powder, calcined cuttlefish bone, above 2 g per medicine powder after 10 g research Take three times a day. All measurements using SPSS 17.0 statistical analysis. Compare the two groups before and after the treatment effect of comprehensive treatment, gastroscope treatment effect, Chinese medicine symptom integral and ulcer area size changes, compared the two groups before and after the treatment the TCM symptom integral, the changes of the two groups of patients were followed up 1 year, observe two groups of 6 months and 12 months ulcer recurrence. Observed two groups of patients during treatment of drug adverse reaction and safety evaluation.Results:(1) Syndromes curative effect observation group total effective rate was 93.33%, the control group was 65.52%, comparing differences between groups was statistically significant (P <0.05).(2) Observation group of gastroscope treatment the total effective rate was 86.67%; Control group total effective rate was 62.07%, comparing differences between groups was statistically significant (P<0.05).(3) Observation group after treatment of TCM syndrome score (7.43-1.24) points, size of ulcer area was (19.89+6.75); The control group after treatment of TCM syndrome score (9.89-2.31), (34.03-10.95) was ulcer area size, comparing differences between groups was statistically significant (P<0.05).(4) From the diagnosis of TCM symptoms of pain, often abdominal distention, belching hiccups, full o eat less, depressed, or irritable, bosom frowsty, lack of burnout and defecate pond thin eight projects were observed, the two groups after treatment the symptom scores were lower than before treatment, after statistics analysis of the difference was statistically significant (P< 0.05). Observation group after treatment of TCM symptom score lower than the control group, comparing differences between groups was statistically significant (P<0.05).(5) On two groups of patients were followed up for 1 year, using the gastroscope to assess patients relapse after treatment, among them 6 months observation group recurrence rate was 6.67%, the control group 6 months recurrence rate was 27.59%; Observation group 12 months the recurrence rate was 26.67%, the control group for 12 months recurrence rate was 51.72%, the comparison between groups was statistically significant difference (P<0.05).(6) Two groups of patients during treatment were not adverse reactions.Conclusion:This topic research suggests the combine traditional Chinese and western medicine in the treatment of peptic ulcer is better than pure western medicine treatment, coating production of powder can significantly improve the clinical signs in patients with peptic ulcer, relieve the suffering of the patients, improve patient quality of life; The mechanism of action of the party is likely to be through improve the immune function of patients with peptic ulcer, strengthen gastric mucosa barrier protection ability and epithelial cell regeneration function; The eradication of helicobacter pylori increased gastric mucosa prostaglandin synthesis protect the gastric mucosa by hydrochloric acid in gastric juice, can increase gastric mucosal circulation, promote the patient of infusion, the energy metabolism of the body, guarantee the mucosal epithelium and the bottom of the ulcer and hyperplasia of edge quickly ensure mucosal microcirculation acid-base balance, improve the ulcer healing effect, reduce the ulcer recurrence. Through the advantages of traditional Chinese medicine to combine traditional Chinese and western medicine treatment, better optimize the clinical treatment of peptic ulcer, reduce the clinical relapse rate, promote the development of the academic level of TCM and to improve the people health level.