The Study Of The Effect Of Tongxinluo On The Intervention Of Atherosclerosis Inflammatory

Objective:This research through the surgical ligation Sprague wrote- Dawley(SD) rats left carotid artery branch part, preparation of low blood flow shear stress under the action of SD rat carotid artery remodeling animal model, the effects of atorvastatin calcium tablet, tongxinluo capsule to prevent and control of the blood vessels of atherosclerosis disease mechanism.Method:Twenty-five Sprague wrote- Dawley(SD) rats were randomly divided into 5 groups(blank group, control group, model group, tongxinluo group, atorvastatin group). Control group: only after the skin incision suture. Model group, tongxinluo group and atorvastatin group by surgical ligation SD rats left carotid artery branch(external carotid, internal carotid artery), part retained with the lateral occipital artery, so that reduce the left common carotid artery blood flow, and the left common carotid arteries were SD rats model of atherosclerosis and stenosis. Atorvastatin calcium tablet and tongxinluo capsule treatment 1 month l through lavag.;Surgery to separate groups of carotid artery, by analyzing the histomorphology changes, research on low blood flow shear stress state of arterial intima morphologic changes and carotid arterial blood tube cavity area and the influence of the thickness of membrane, membrane, observation analysis of atorvastatin calcium tablet, tongxinluo capsule on vascular remodeling effect; 。Immunohistochemistry animal model to analyze the impact of low shear stress on the left common carotid artery and CD68 protein expression of iNOS protein. Discussion atorvastatin calcium, Tongxinluo capsule on the expression of the relevant factors for atherosclerosis in inflammation.Result1.There are not signification influence to the animals heart rate,weight and systolic blood pressure after ligation left carotid artery branch.2.Surgical ligation of left common carotid artery branch, can significantly reduce the surgical group animals left common carotid artery blood flow(p < 0.01 vs control), cause its luminal stenosis of the left common carotid artery, and the left carotid artery intimal thickening, in the film(p < 0.01 vs control, sham), the higher the left common carotid artery iNOS protein(p < 0.05 vs control, sham), CD68(p < 0.05 vs control, sham) expression.3. Atorvastatin calcium tablet, tongxinluo capsule can significantly reduce the low shear force caused by the left common carotid artery blood flow tube cavity area is narrow, at the same time reduce the thickness of the membrane in the left carotid artery intima(#p<0.05 vs model);4. Atorvastatin, tongxinluo capsule can inhibit low blood flow shear force caused by the left common carotid artery iNOS protein,CD68 protein(#p<0.05,vs model) lower expressionConclusion1.Atorvastatin calcium tablet through its protecting endothelial function, anti-inflammatory function improved significantly lower hemodynamic changes caused by the left common carotid artery vascular remodeling and lining in the membrane thickening.2. The mechanism of action of tongxinluo capsule is closely related to the diastolic blood vessels and anti-inflammatory effects...