Nose Capsule Part Of The Pharmacodynamics And Anti-inflammatory Mechanism

BiKang capsule has the effects of dredging opening and relieving pain, clearing away heat-evil and eliminating toxic materials,promoting blood circulation and removing gore.Using BiKang capsule to treat acute rhinitis,chronic rhinitis and allergic rhinitis and so on has preferable effects.In order to crystallize its pharmacological effects and anti-inflammatory mechanism,the experiments as follows have carried out: By means of the swelling of mice ears induced by xylene, swelling of granulation in cotton ball and the penetrating of blood capillary in abdominal cavity to test and verify the anti-inflammatory effects of BiKang capsule; by means of mice pain caused by hot board and mice twisting bodies caused by acetic acid to test and verify the analgesic effects;by means of copying the mice model of rhinitis and measuring the activities of IL-1 and TNF to test and verify its teatment and affecting the activities of IL-1 and TNF.Results: BiKang capsule can significantly inhibit swelling of mice ears induced by xylene, swelling of the penetration of blood capillary in abdominal cavity and granulation in cotton ball. Bikang capsule can enhance the threshold of pain of mice pain caused by hot board and acetic acid.BiKang capsule has the favorable treatment for the mice model of rhinitis and can depress the activities of IL-1 and TNF.Conclusion: BiKang capsule has the significantly effects of anti-inflammatory and analgesic effects.BiKang capsule has the favorable treatment for rhinitis,and the mechanism of anti-inflammatory action is related to depress activities of IL-1 and TNF.