The Clinical Observation Of Xiaoyao Powder In Treating Bile Reflux Gastritis(hepatic Stagnation And Spleen Deficiency Type) And Its Influnence On Plasma Motilin(MTL)

Objective: Through observing the change of plasma motilin of the bile reflux gastritis(BRG) patients(hepatic stagnation and spleen deficiency type) in the test group and control group before and after treatment to analysis the mechanisms of Xiaoyao powder in treatment of bile reflux gastritis(hepatic stagnation and spleen deficiency type).By comparing of the improvement of clinical symptoms of patients before and after treatment to observe the clinical efficacy of the therapy of bile reflux gastritis(hepatic stagnation and spleen deficiency type) combined clinical medicine with Xiaoyao powder.Methods: 60 cases in accordance with the test criteria were collected, and were randomly divided into the treatment group 30 cases and control group 30 cases, and statistical analysis of the two groups in age, gender, disease duration and bile reflux conditions.The treatment group were given xiaoyao powder every day in two times and Domperidone(Motilium) tablets 10 mg half an hour before three meals a day and Omeprazole capsules 20 mg half an hour before two meals every day.While the control group were just given western treatment, such as Domperidone(Motilium) tablets 10 mg half an hour before three meals a day and Omeprazole capsules 20 mg half an hour before two meals every day. Each groups were treatmented for two months.At the same time 2ml blood were obtained in first time patients and their plasma motilin(MTL) levels were detected by radioimmunoassy, and their Chinese medical symptoms and endoscopy results were recorded. After treatment use the same method to collect all the indexes and make curative effect evaluation by comparing the two groups of patients.Results: 1.The total effective rate and efficacy of TCM symptoms after treatment of the two groups both showed significant difference(P<0.05).The TCM symptoms effective rate of the treatment groups was 96.67% while the control groups 86.67%.2. The TCM symptoms of the two groups were both lesser than before treatment(P<0.05)which showed that both method could improve the TCM symptoms. To compare the integral TCM symptoms differences of the two groups before and after treatment, the treatment group were better than the control group(P<0.05) which showed that the the treatment group was better than the control group to improve the TCM symptoms.3. After treatment, the bile reflux grading of two groups were significantly lesser than before treatment(P<0.05), But there was no significant difference between two groups after treatment(P<0.05).4. After treatment, the plasma MTL levels of two groups were significantly higher than before treatment(P<0.05), and the treatment increased more obviously than the control groups. There was a significant difference between the plasma MTL levels of the two groups after treatment(P<0.05)which showed that the treatment group was better than the control group to increase the level of MTL.5. The correlation between the TCM symptoms and plasma MTL was negative(r<0, p<0.05).6. Two groups of patients both could tolerate and complete the test without no untoward.Conclusion: Xiaoyao power combined with Domperidone(Motilium) tablets and Omeprazole capsules in treatment of bile reflux gastritis(hepatic stagnation and spleen deficiency type)possibly by improving patients’ s clinical anxiety, depression and mental symptoms, and improving the level of plasma MTL and coordinating the movement of gasric and duodenal and improving the gastrointestinal motility.