The Research And Preparation Of Nasal Hemostatic Materials

In our country, there are a lot of people suffer from rhinitis, nasal polyps and nasal diseases. Environmental pollution, the air condition such as external stimuli are more likely to worsen body condition. Currently, the nasal endoscopic surgery is an effective method for treatment of nasal disease. The success of nasal endoscopic surgery is closely related to the properties of nasal packing hemostatic materials. Poor performance of the nasal packing hemostatic materials easily lead to nasal packing failure, increase the pain of the patients during tamponed hemostasis, and may cause complex syndrome. the current Otolaryngology clinical practice using high-quality nasal packing hemostasis materials are foreign products, however, these expensive foreign is poor biological compatibility and easily induce inflammation. The domestic nasal packing hemostasis material performance is generally poor, so domestic development the good performance of the nasal packing material is necessary. Carboxymethyl chitosan (CMCS) has proven to be have good potential medical application of biological materials, but chitosan foam material is brittle, easy to dissolve and is easily residue in the human body.This paper tries to use the flexible polymer to modify the CMCS foam materials, especially on the toughening modification, and the main toughening material is polyvinyl alcohol (PVOH) and polyethylene glycol (PEG).(1)First of all, this paper test the performance of the experimental materials. In this paper measured the data of molecular weight, dissolving properties, and other physical or chemical properties. The results showed that CMCS molecular weight is 150000, and the decollation degree is 90%.(2)In this paper, we modified CMCS by PEG, and propagated the PEG/CMCS composite materials.Experimental results show that this composite materials are not suitable for nasal packing materials.(3)In this paper, we modified CMCS by PVOH, and propagated the PVOH/CMCS composite materials. The water absorption test show that this materials are hydrophilic, and the water quantity is ten times itself weight. Mechanical performance test show that PVOH can improve the chitosan sponge toughness. Degradation experiments showed that PVOH does not change the material degradation.(4)Biological experiments show that PVOH/CMCS hemostatic sponge are biological affinity. This materials can degrade in the body, and degradation products are not harmful to human. This is an excellent hemostatic packing material.