Research On The Artificial Bone With Composite Structure Based On 3D Printing Manufacturing Technology

Skeleton is the support structure of human body. It has a very important influence on keeping healthy. For a small range and slight bone injury, bone tissue has self-healing capability. But in most cases, bone is unable to repair itself from lesions and trauma. So transplantation of artificial bone scaffold to promote healing of damaged bone tissue is necessary. One characteristic of the natural bone is porous, and the three-dimensional pores link to each other. To ensure the biological activity of artificial bone scaffold, the internal structure of artificial bone scaffold should be designed as bionic structure with evenly distributed pore and three-dimensional orthogonal overlapping microtubules. Aimed at the problems in the molding process, each step was analyzed in detail in this thesis.The influence of different microstructure and the overall appearance of theartificial bone scaffold under the condition of the body’s natural bone stress was analyzed. The main purpose of this thesis is to research molding process, so artificial bone scaffolds with regular microstructure and macrostructure were designed. Based on the simulation analysis of different parameters, finally the cubical in general outline and cylindrical internal flow channel were determined of the artificial bone scaffold.The preparation process was researched, and the more convenient injection molding former was designed. It solves the problems caused by the manual filling method, such as inaccuracy of dosage, uneven filling, air bubble, uneven freezing, inaccurate uploading, difficult controlling of load and not easy to demould etc.The impacts of the materials of the molds on the artificial bone scaffold were investigated. The appropriate material was selected to solve the pollutants and broken of the scaffolds. To select the filler material according to the specific circumstances, To set heating temperature according to the simulation analysis of temperature field.Because the mechanical properties of single material scaffold are poorer, the scaffold with the composite structure that is made of Ti-alloy and bioactive ceramic was designed. The composite structural scaffold can avoid the poor biocompatibility of Ti-alloy scaffold and the poor mechanical properties of bioactive ceramic scaffold.