| Objectives To investigate the relationship between serum renin, aldosterone and hemoglobin, age and other routine biochemical parameters and diabetic nephropathy in patients with type 2 diabetes mellitus(T2DM),which in order to provide theoretical basis for the prevention and treatment of diabetic nephropathy(DN).Methods 216 type 2 diabetic patients were selected from Hebei United University Affiliated Hospital and divided into control group(the diabetic group,144cases) and DN group(72cases)according whether the patients with and without diabetes stage III and IV diabetic nephropathy.All patients were recorded the dates as follow. systolic blood pressure, diastolic blood pressure, body mass index(BMI), fasting plasma glucose(FPG), glycosylated hemoglobin(Hb A1c), triglyceride(TG), total cholesterol(TC), low density lipoprotein(LDL-C), high density lipoprotein(HDL-C), aldosterone and renin(PRA). All the dates were analyzed by the spss21.0 statistical software package as follows:normal distribution measurement data using mean ± standard deviation, an independent samples t-test in mean compared, chi square test in count data, Pearson correlation coefficient analysis between the PRA level and age, course of disease, BMI, FPG, Hb A1 c and systolic blood pressure, diastolic blood pressure, TC, TG, HDL-C, LDL-C, and calculating the correlation coefficient, Logistic regression analysis the risk factors of diabetic nephropathy to observate the indicators which influence the level of renin(P < 0.05 were considered to be statistically significant).Results. 1. Compared with the control group, there was no significant among sex, age, systolic blood pressure and diastolic blood pressure in DN group(P > 0.05),while the disease course and BMI was statistically significant(P < 0.05). 2. DN group had significantly higher Hb A1 c levels than control group(P < 0.05). 3. Serum TG, TC and LDL-C in DN group were significantly higher than those in control group, while HDL-C was lower(P < 0.05). 4. Surm PRA level between DN group and control group were different(P < 0.05). 5 when the PRA level was lower than the normal range, the risk of patients with III and IV stage diabetes nephropathy increased by 6.781 times. 6. Surm aldosterone levels had no difference in the group of patients with III and IV stage diabetes nephropathy and non diabetes nephropathy group(P > 0.05). 7.as the factor of with or without III and IV stage diabetes nephropathy for the dependent variable duration, BMI, PRA, ALD, TG, TC, HDL-C, Hb A1 c as independent variables, to continue the multiple factor non conditional logistic regression analysis, the results showed III and IV stage diabetes nephropathy had negatively correlation with the disease duration, TC, TG, Hb A1 c, BMI(P < 0.05), and other indexes had no correlation(P > 0.05). 8.the level of PRA had no correlation with gender, BMI, systolic blood pressure, diastolic blood pressure, hs-CRP and FPG(P > 0.05),while negatively correlated with the disease duration, age, TC, Hb A1 c, TG and LDL-C(P < 0.05), positively correlated with HDL-C(P < 0.05). 9.By stepwise multiple linear regression analysis, The results showed that the PRA level and aldosterone, HDL-C were positively correlated, and age, disease duration, TC showed negative correlation, P < 0.05),while other indicators had no correlation(P > 0.05).Conclusions 1. Serum PRA level in type 2 diabetes patients decreased gradually with the increase of the disease duration.2. Serum PRA level in type 2 diabetes patients with diabetic nephropathy was significantly lower than non diabetic nephropathy, and serum PRA level was positively correlated with aldosterone and HDL-C, negatively correlated with age, disease duration, TC. 3..When the PRA level was lower than the normal range, the risk of patients with III and IV stage diabetes nephropathy increased in type 2 diabetes patients. |
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