Effects Of Oxytocin Administrated By Intravenous Drip In Labor On Neonatal Jaundice

Objective Through the discussion of different doses of intravenous drip of oxytocin in labor factors of neonatal pathological jaundice, guide the clinical application of a reasonable, effective, timely, appropriate amount of oxytocin.Methods 1. The research object The inclusion criteria: The study of normal full-term newborns were randomly selected from Yan’an University Affiliated Hospital obstetricsim in 2014 July-2015 year in January admitted to the delivery of full-term pregnancy, including indications for labor induction, application of different doses of oxytocin administration after 90 cases of neonatal vaginal delivery, and 30 cases without the use of oxytocin after vaginal delivery of newborns. 2. Methods 2.1 Data collection: every newborn met the inclusion criteria, in accordance with the mothers in labor so drip of oxytocin in total dose of different groups was as follows: use of oxytocin dosage in 2.5U-5.0U(5) in group A(low dose group), use of oxytocin in the total 5.0U-7.5U(not including 5 7.5), including neonatal group B(middle dose group), use of oxytocin in the total 7.5-10U(not including the 7.5, including 10) in group C(high dose group), each group were randomly selected 30 cases, were randomly selected without the use of oxytocin were successful vaginal delivery in 30 cases as control group. Record the basic information between groups, such as maternal age, total labor time, fetal sex and birth weight and other general information and after birth first days- seventh days every transcutaneous bilirubin values. To investigate the effect of the incidence of neonatal pathological jaundice and the relationship between. 2.2 Data analysis: for each newborn admission standards, first days after birth and seventh days to record the transcutaneous bilirubin values, including the forehead and chest, and take the average of production process at different doses of oxytocin drip leading influencing factors of neonatal pathological jaundice. To investigate the pathological jaundice in newborn groups the incidence, the incidence of comparison, further guide clinical rational use of appropriate and timely oxytocin. 2.3 Statistical methods: the establishment of the database to Microsoft Excel, using SPSS 19 statistical software package was used for statistical analysis. Using single factor analysis of variance method compared with the control group, group A(low dose group), group B(middle dose group), C(high dose group) general information on maternal age, birth weight, birth process. Chi square cross categorical data using the Rx C list of the test to compare different doses of oxytocin group of pathological jaundice of newborn morbidity differences.Results 1. Comparing the results of basic data Four groups of maternal age, total labor time and neonatal birth weight, the A group compared with control group, single factor analysis of variance(low dose group), group B(middle dose group), C group(high dose group) of maternal age, birth weight, birth process, results showed that, yield women age(F=1.583, P=0.197), labor(F=2.520, P=0.061), birth weight(F=0.165, P=0.920) were no significant difference between the groups.(P >0.05). 2. Different doses of oxytocin group and the control group the incidence of neonatal pathological jaundice rate and its correlation Group A(low dose group) the incidence of neonatal pathological jaundice was 3.45%, group B(middle dose group) the incidence of neonatal pathological jaundice rate was 6.67%, C group(high dose group) the incidence of neonatal pathological jaundice was 30%, the control group of neonatal pathological jaundice disease incidence rate is 3.45%, A group B group and the incidence of neonatal pathological jaundice were compared, the difference was not statistically significant(X2=0.351, P=0.554). In A group, B group compared with the control group, the difference was not statistically significant(X2(A) =0.000, X2(B) =0.351, P(A) =1.000, P(B) =0.554). In A group, B group and C group, the difference was statistically significant(X2(AC) =7.680, X2(BC) =5.545, P(AC) =0.006, P(BC) =0.020). C group and the control group the incidence of neonatal pathological jaundice were compared, the difference was statistically significant(X2=7.680, P=0.006).Conclusions 1. In the birth process, the amount of use of oxytocin in less than 7.5U, no significant effect on occurrence of neonatal pathological jaundice. 2. The stage of labor with a total dose of oxytocin in between 7.5U-10 U, can promote the occurrence of pathological jaundice; production process using high doses of oxytocin is low, dose of oxytocin on the occurrence of pathological jaundice of newborn effects have significant differences, and was positively correlated with the increase of oxytocin dose, the incidence of pathologic jaundice rate is high. 3. Groups of neonatal transcutaneous comparison after the birth of a week in each group had no significant difference between the value of bile.