Expression Of MAD2 In Bladder Urothelial Carcinoma And Its Clinical Significance

Objective:To investigate the expression of Mitotic arrest deficient protein 2(MAD2) in Bladder Urothelial Carcinoma(BUC) and the relationship between MAD2 expression and pathological grading, clinical stage and prognosis of BUC.Methods:Determined the expression of MAD2 by immunohistochemical staining on tissue in 47 cases of BUC and 12 cases of normal bladder and elucidate its association with histological grade, clinical stages and recurrence. The Data management and statistical analyses were performed with SPSS 13.0.Numeration data performed using Chi-squared or Fisher exact tests. Median survival time were analyzed with Kaplan–Meier curves and a P value <0.05 was considered statistically significant.Results:The positive expression rate of MAD2(72.3%) in BUC was higher than those of tissues of normal bladder(P<0.05).Furthermore, The positive expression rate of MAD2 in the high-grade(85.7%vs33.3%,P<0.05) and the invasive BUC(78.9%vs 33.3%, P<0.05) were significantly higher than those of low-grade and the superficial BUC. However, there was no statistically significant difference for the positive rate of MAD2 between the recurred cases and primary cases(P>0.05). In addition, the patients with higher expression of MAD2 had a shorter survival time(50 months vs 78 months P<0.05).Conclusion:MAD2 might be an important marker in the diagnosis of BUC. The detection of MAD2 can predict the degree of malignancy and prognosis, providing the theoretical basis for clinical treatment.