Retrospective Analysis Of Transurethral Resection In Treating Urothelial Cell Carcinoma Of Bladder Combined With BPH

Objective:To explore the curative effect and feasibility of transurethral resection in the simultaneous treatment of urothelial cell carcinoma of bladder(UCCB) with benign prostatic hyperplasia(BPH).Methods:37 cases with UCCB and BPH in Qinghai University Affiliated Hospital were enrolled into this study from March 2013 to December 2014.The patients were divided into two groups,17 cases(group A) receiving transurethral bladder tumor resection,and 20 cases(group B) receiving both transurethral prostate resection and transurethral bladder tumor resection at the same operation.The recurrence and progression rate,relapse time,the recurrence rate in the bladder neck and prostatic urethra were compared between two groups.The maximum flow rate(Qmax),residual urine volume(RUV),international prostate symptom score(IPSS) and quality of life(QOL) were observed,analysis of the efficacy and safety.Results: All operations were conducted successfully. Micturition of 37 patients became smooth. Reoccurrence was found in 3 cases in Group A, with a recurrence rate of 17.6% and a mean recurrence interval of 10.6 months; Reoccurrence was found in 2 cases in Group B, with a recurrence rate of 10% and a mean recurrence interval of 11.7 months. There were no statistically significant differences in recurrence rate and interval between the two groups(P>0.05). During the follow-up period, no implantation metastasis in the prostatic cavity was observed in both groups.Implantation metastasis in the bladder neck occurred in 1 case in Group A 10 months after operation, the same metastasis occurred in 1 case in Group B 12 months after operation. There were no statistically significant differences in the rates of implantation metastasis in the bladder neck and prostatic cavity between the two groups(P>0.05).The IPSS decreased from(17.9±6.9) to(8.3±2.2) and the RUV volume decreased from(104.1±30.2)ml to(18.3±7.9)ml.The Qmax increased from(7.7±1.5)ml/s to(19.7±6.5)ml/s and the QOL decreased from(4.3±0.6) to(1.8±0.9),P<0.05.Conclusion:Transurethral resection has marked curative effect in the treatment for urothelial cell carcinoma of bladder(UCCB) with benign prostatic hyperplasia(BPH).Moreover, it is a safe and reliable method that will not increase the risk of tumor implantation and needs further more clinical researches and applications.