To Investigate The Distribution Of TCM Syndrome Of Mild Cognitive Impairment

Object:This study was aimed to find the traditional chinese medicine(TCM) distribution of the mild cognitive impairment(MCI) for the older group and the non-elderly group,which under the guidance of TCM theory and doing a unified survey of TCM syndrome, preventing Alzheimer’s Disease. Methods:1. All eligible eases were in accordance, with the unified design standard survey, clinical including:1)General information: hospital number, demographic characteristics, medical history,etc.2)Western diagnostic criteria: Diagnostic criteria for mild cognitive impairment in elderly.3)Chinese diagnostic criteria: Refer to "TCM Deficiency Syndrome Reference Standard" and "TCM clinical diagnosis term" relevant diagnostic criteria, and clinical symptoms, tongue, pulse and so on. And use The Scale for the Differentiation of Syndrome of Vaseulardementia(SDSVD) formulated by Tian Jinzhou, establish five syndromes Syndrome diagnosis: kinney essence deficiency, sptum turbidity resistance orifices, liver Yang hyperactivity, blood stasis resistance winding, blood deficiency. Compile syndrome scale, every syndrome out of 30 fraction, greater than 7 fraction was established.2. Using neuropsychological tests scale to assess patients, included: Minimum Mental State Examination( MMSE),Montreal cognitive Assessment(Mo CA),Activity of Daily Living Scale,(ADL),Hamilton Anxiety Scale(HAMD),Global Deterioration Scale(GDS),Clinical Dementia Rating(CDR).3. This study selected patients diagnosis of MCI which came from the integration of traditional Chinese and Western medicine ward and out-patient clinic of Affiliated Hospital of Hebei University. from October,2012 to October 2014.All the data was entered, we checked them again to ensure no error.4. This study used SPSS16.0 to analysis data. Catgorical data was expressed by frequency and perentage. While the measurement data was expressed by mean± standard deviation. When P value<0.05,we considered the test had statistically signicant difference. Results:1. Sex,risk factor,education:By Chi-square test, the gender composition of the older group and the non-elderly showed no significant difference. But the risk factors and education of the two groups significant difference.2. The MMSE integration and MOCA integration:By t-test, the MMSE integration and MOCA integration of the two groups were not statistically significant difference.3. TCM Syndrome: The older group had 77(78.57%) kinney essence deficiency patients,17(17.35%) phlegm blocking orifices patients,19(19.39%)blood stasis resistance winding patients,24(24.50%) liver Yang hyperactivity patients, and 61(62.24%)blood deficiency patients, and the non-elderly group had 13(20.97%) kinney essence deficiency patients,52(83.87%) phlegm blocking orifices patients,43(69.35%)blood stasis resistance winding patients,17(27.42%) liver Yang hyperactivity patients, and 15(24.19%)blood deficiency patients. By Chi-square test,the two groups had statistically significant difference. That TCM syndrome of the two groups was significant difference. The older group is mainly kinney essence deficiency and blood deficiency, and the non-eldery group is mainly sptum turbidity resistance orifices and blood stasis resistance winding. Whatever older group or non-eldery group, complex syndrome is common.4. TCM Syndrome integration: By the two groups t-test, according to α = 0.05 standard, the TCM syndrome integration of kinney essence deficiency, phlegm blocking orifices, blood stasis resistance winding, blood deficiency had statistical significance. That the TCM syndrome of kinney essence deficiency, phlegm blocking orifices, blood stasis resistance winding, blood deficiency in the older group and non-eldery group distributed differently. Liver Yang hyperactivity of two groups was not statistically significant difference. Conclusion:The Distribution of TCM Syndrome of mild cognitive impairment, over 65 years older patients is mainly deficiency syndrome of kinney essence deficiency and blood deficiency, but under 65 years old yong patients is mainly empirical syndrome of sptum turbidity resistance orifices and blood stasis resistance winding. The onset of MCI associated with the education and hypertension, diabetes, dyslipidemia and coronary heart disease and other factors have a close relationship.