Relationship Between Skeletal Muscle Loss And Bone Mineral Density In Hospitalized Elderly People

Objectives:The aims of this study were to investigate the relationship between appendicular-skeletal muscle mass (ASMM), relative skeletal muscle index (RSMI) and bone mineral density (BMD) in hospitalized elderly people, and the relationship between skeletal muscle loss, osteoporosis and fragility fracture, exploring new ideas for the prevention of osteoporosis and fragility fracture,methods:Height, weight, body mass index (BMI), ASMM, RSMI, BMD and T-sore at different sites, fat% were studied in 562 elderly from The First Affiliated Hospital of Chongqing Medical University, using dual-energy X-ray absorptiometry (DXA).Pearson’s correlation analysis was used to estimate associations between different variables about patient’s general characteristics, and relationships between skeletal muscle loss, osteoporosis and fragility fracture were estimated by logistic regression analysis.Results:RSMI had significantly positive correlation with BMD in both genders (Lumbar:male r=0.203, P<0.01, female r=0.165, P<0.01; Hip:male r=0.253, P<0.01, female r=0.225, P<0.01), and also had highly positive correlation with BMI (male r=0.777, P<0.01, female r=0.791, P<0.01); BMD had significantly positive correlation with BMI (Lumbar:male r=0.319, P<0.01, female r=0.236, P<0.01; Hip:male r=0.199, P<0.01, female r=0.211, P< 0.01). The prevalence of osteoporosis and fragility fracture were significantly higher in elderly women patients, while men suffered more skeletal muscle loss. Men with skeletal muscle loss had a higher risk of osteoporosis in the elderly(β=0.774, P=0.002, OR=2.168), but this relationship does not exist in women (P> 0.05). Fragility fracture had significantly positive correlation with both osteoporosis and skeletal muscle loss in elderly(P< 0.05=.Conclusions:In the elderly, bone and muscle had close relationship; osteoporosis and skeletal muscle loss had obvious gender differences: significantly positive correlation in men, and no relationship in women. Fragility fracture had close relationship with both osteoporosis and skeletal muscle loss. Raising muscle mass is significant for the prevention of osteoporosis and fragility fracture.