| Background:Oral cavity compressed moss is the clinical common disease of the oral mucosa, incidence of a disease is second only to recurrent ulcer him, because of its long-term erosion disease progression in damage, the world health organization(who) will it as a precancerous condition.Clinical symptoms in patients with oral squamous moss to mucosa more discomfort, local sensitive feeling, burning pain is given priority to, so a lot of patients early in the disease do not have enough attention, often repeatedly, development to the widespread erosion surface of long-term don’t heal, to go to a doctor, clinical treatment is relatively difficult, and greater risk of cancer.Due to illness need biopsy diagnosis, on the existing damage to bring iatrogenic trauma, and is not conducive to disease recovery, so clinicians in the face of widespread erosion patients, the first is the conventional treatment ways to control inflammation, the body immunity, personalized therapy for individual patients do, treat disease situation is stable, whether based on erosion surface within the scope of the benign recovery, further determine whether need to biopsy for pathological examination.But oral illness alleviates the flat moss is a long process, during which according to the effects of reaction need to continue to adjust the treatment plan, if meet the condition of stubborn sex, recovery time is longer.So the result is a kind of phenomenon, oral cancer diagnosis often compressed moss in the clinical diagnosis of patients with oral squamous moss after a long time, many cancer patients with oral cavity compressed moss missed the relatively better treatment time.Needle in this situation, the current related research it all the time, whether can have a kind of effective and relatively noninvasive method for oral cavity compressed moss whether make a diagnosis of cancer, that can guide clinical reasonable treatment, early in the development of oral squamous moss into oral squamous cell carcinoma before the illness under control.Before in order to solve this problem, immunology and gene research is more, but have not yet got good results.In recent years, the study of protein in oral squamous cell carcinoma(become a hot spot, the reports of VEGF and MMP- 9 in oral squamous cell carcinoma(SCC) play an important role in the development process, this study based on the theoretical basis, of VEGF in oral cavity compressed moss moss and the expression of MMP- 9 cases analysis, compared with oral squamous cell carcinoma, and explore the VEGF and MMP- 9 if there is a correlation with cancer of the oral cavity compressed moss. Objective:Detection of VEGF and MMP- 9 expression in oral squamous moss and oral squamous cell carcinoma, and to explore the expression of the relationship between cancerous oral squamous moss, analysis the correlation between them at the same time, to look forward to in the further research whether can through the VEGF and MMP- 9 test for early diagnosis of OLP canceration, so as to better guide clinical treatment. Methods:Using immunohistochemical staining(S-P method) detection of 11 cases of NOM, 18 cases of OLP and 35 cases of OSCC tissues VEGF and MMP- 9 expression, SPSS19.0 software is used to analyse the experimental results for data processing, is analyzed by chi-square test, the use of Spearman system of OLP and the correlation between VEGF and MMP- 9 in OSCC were analyzed, and further explore VEGF and correlation in the process of MMP- 9 in OLP canceration. Results:1. The VEGF in NOM organization without express or extremely low expression, in OLP and OSCC tissues can see the expression of different level.After statistics analysis, on the expression of VEGF, normal group compared with OLP and OSCC group were significant difference(P < 0.05), OSCC expression was significantly higher than that of OLP group(P < o. 05).2. MMP- 9 in NOM organization without express or extremely low expression, in OLP and OSCC tissues can see the expression of different level.After statistics analysis, on the expression of MMP- 9, normal group compared with OLP and OSCC group were significant difference(P < 0.05), OSCC expression was significantly higher than that of OLP group(P < o. 05).3. The VEGF expression and the expression of MMP- 9 was significantly positive correlation(p < 0.01), that is, both in OLP and expression level of OSCC tissues has a tendency to increase or decrease at the same time. Conclusion:1. The VEGF expression level was significantly higher in the OLP and OSCC tissues than NOM, and presents the tendency of gradually increased, prompt VEGF may be closely linked with OLP canceration.2. The MMP- 9 expression level was significantly higher in the OLP and OSCC tissues than NOM, and presents the tendency of gradually increased, prompt MMP- 9 may be closely linked with OLP canceration.3. VEGF and MMP- 9 in OLP and the role of the occurrence and development of OSCC exist significant correlation, MMP- 9 may participate in the VEGF in OLP lesions develop process of OSCC, both for synergy. |
