The Research Of Clinical Characteristics Of Occupational Asthma And Airway Inflammation Characteristic

Objective:To discuss the airway inflammation differences between occupational asthma (OA) and allergic asthma (AA).Methods:The sampling survey will be used and 20 patients respectively of OA and AA in non-acute episode phase can be regarded as the groups OA and AA. The control degree of asthma shall be evaluated through adopting questionnaire score of ACT and FEV1%. The peripheral blood EOS% and the level of serum IgE are collected. Some immunological indicators are collected such as sputum induction EOS%, NEUT%, IL-4, IL-8 and IL-13, ECP and MPO level. Results:The comparison of ACT scores and FEV1% between patients from groups OA and AA shows no statistical meaning in their differences[(20.6±2.2) vs (19.9±3.0)scores, (70.9±4.5)% vs (68.9±4.0)%. The peripheral blood EOS% and immunoglobulin E T-IgE of patients of group OA are lower than those of group AA[(79.9±13.8) x103 Vs (458.8±34.9)×103 U/L, (2.5±1.1)% vs (3.9±1.4)%, P< 0.01]. EOS%, IL-4, IL-13 and ECP level in induced sputum of group OA are lower than those of group AA. [(5.9±2.1)% vs (14.9±2.4)%, (16.5±3.1) vs (23.9±2.4) μg/L, (44.9±3.4) vs (58.4±2.4) μg/L, (33.6±16.5) vs (89.5±24.5) μg/L, P<0.01), NEUT%, IL-8 and MPO level are higher than those of group AA [(57.8±9.7)% vs (33.9±3.6)%, (735.9±102.1) vs (414.9±112.4) μg/L, (3.9±0.6) vs (2.7±0.5) μg/L, P<0.01]. The EOS% in induced sputum of patients from groups OA and AA are higher than the peripheral blood EOS%(P<0.01) of patients in the same groups. Conclusion: There has difference between airway inflammatory response of group OA and those of AA. Some immunological indicators tests like EOS%, NEUT%, IL-8, IL-4, IL-13, ECP and MPO have certain clinical significance to differential diagnosis of group OA.