| Background Esophageal carcinoma is a common digestive tract tumor. The male is about 31.66/100000, and the female is about 15.93/100000, which accounts for second of all cancer deaths. Over the years, clinicians have been committed to the study of prognostic factors affecting the prognosis of esophageal cancer, involving a variety of factors, on the current research results, esophageal cancer in the United States is not common, the annual new case of about 10000 to 12000 cases. Unfortunately, most of the patients in our country in the treatment of late, so the effect is poor. Although the surgical technique and perioperative management of the patients with significant progress, there are a variety of new chemotherapy drugs come out, but the total 5 year survival rate of esophageal cancer is still between 5%～10%. The prognosis of esophageal carcinoma is the result of many factors, many steps, and the comprehensive effect of the system, which need to be further studied. A summary of the relevant research results on the prognosis of esophageal carcinoma.Objective To investigate esophageal cancer patients’ present conditions and the influence factors is to offer help to improve the long-term survival of them.Method1 The object of study1.1 The object and the inclusion criteria of study objectThe study surveyed total of 1145 individuals with EC. After rigorous screening by the same criteria the author followed up them by telephone and home visits. the follow-up deadline is May 31,2014.The inclusion criteria are as follows:①Pathological diagnosis is esophageal cancer and has straightforward survival time;② Home address or phone were registered clearly and can follow-up to the patients or their families;③ Medical record number and pathological number were detailed, as well as medical history information were completed;④ All subjects were treated (surgery, radiotherapy, chemotherapy)⑤ In order to exclude duplicated investigation which results from the patients going to the different hospitals and regions, each family only has one contact person at investigation.1.2 general situation of study objectThere are 724 male cases, the youngest was 29 years old, maximum age was 81 years and the mean ages were 55.794±8.756;There are 421 female cases, the youngest was 31 years old, maximum age was 84 years and the mean ages were 55.314±8.578 years.2 The investigation of epidemiologyFollow up of the patients were followed up, family follow-up, but still take telephone follow-up and research as the main means, the content of the patient’s gender and age, and other general information and the patient’s pathological data and so on.3 Statistical analysisSPSS 17.Ostatistical software analysis, Statistical methods Log-rank were selected to choose the difference between the survival time of each group. Cox regression calculate risk ratio (Hazard Ratlos, HR). Adjusting the age and sex of the patients, the family history of different prognosis, the location of esophageal cancer, the degree of pathological differentiation, TNM stage, blood type and the clinical factors were adjusted, On the basis of single factor analysis, the standard is a=0.05. In the treatment method, the use of multiple factor analysis, the difference was statistically significant P<0.05.Results1 There is no significant difference in survival between men and women (P=0.102), and there is no significant difference between male and female patients (HR=1.086), but the difference is not statistically significant (P=0.141)2 There is no statistical significance (P=0.059) on the survival time of different age groups.65 years of age or older than 35 years of age, the mortality risk is significantly decreased by 69%(HR=0.032), with statistical significance (P=0.031)3 There are no statistical differences in overall survival (P=0.338) of three common patients with esophageal cancer. The risk of death in the middle and upper segments is significantly higher than that of the lower segment (HR=2.010), and the difference is statistically significant (P=0.043)4 The degree of differentiation is not statistically significant (P=0.491). The risk of death in patients with poorly differentiated patients is elevated (HR=1.697; HR=1.605), but no significant difference is statistically significant (P=0.239; P=0.256)5 In terms of disease staging, there are statistically significant differences in the survival time between patients with different stages (.P=00000), and the risk of death is significantly higher in patients with middle and advanced stage than in earlier stage HR=1.698;HR=2.259), and there are significant differences in the mortality risk between them (P=0.003)6 The survival time of patients with family history is higher than that of patients without family history (P=1.19E-06), and Cox regression showed that the risk of death is significantly higher than that of patients with no family history (HR=0.59), with statistical difference (P=2.78E-06)7 There is no significant difference in survival time between patients with different blood groups (P=0.358)8 patients with surgery combined with radiotherapy and chemotherapy is significantly higher than those of the simple operation, the difference is statistically significant (P<0.05), and the rest of the treatment mode, two two compared with no significant difference in survival (P>0.05)Conclusion The prognosis of EC are statistically correlated with clinical stage,family history of EC,age of surgery and surgical methods; There are no statistically correlated with gender,age, overall, degree, blood. |
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