Analysis The Characteristics And Its Influence Factors Of Coronary Artery Lesions Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective: Analysis the characteristics and its influence factors of coronary artery lesions in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Method:Selected 120 patients undergoing sleep apnea monitoring and coronary angiography, they were divided into 3 groups according to apnea hypopnea index(AHI): AHI<10 /h group(control group, n=25), 10~15 /h for mild OSAHS group(mild group, n=32), and >15 /h for moderate to severe OSAHS group(moderate-severe group, n=63). The clinical data and laboratory test results were collected. And the data by means of the single factor analysis and Logistic regression analysis to analysis characteristics of coronary artery lesions in patients with OSAHS and its influence.Results:(1) the basic data comparison:smoking, BMI, blood glucose, blood lipid and blood pressure were compared among the three groups had no significant difference, but the age was statistically significant difference(P<0.05).(2) the results of coronary angiography show that these three groups has significant differences in revealed anterior descending coronary artery disease,right coronary artery disease, single vessel disease and the incidence of coronary heart disease(P < 0.05).the rate of these disease in the severe group is higher than mild group,and the incidence of coronary heart disease in the severe group is higher than that in the control group(P<0.0167).(3) multivariate Logistic regression analysis shows that:,drinking(OR=7.058,95%CI 1.953-25.508), age(OR=1.845,95%CI 1.121-3.038), apnea index(AHI)(OR=2.404,95%CI 1.088-5.314) are the main risk factors of coronary artery disease;alcohol(OR=12.114,95%CI 3.058-47.979), AHI(OR=3.052,95%CI1.210-7.694)are the main risk factors for single vessel disease;age(OR=2.812,95%CI1.236-6.400)is the main risk factor for multiple vessel disease.Conclusion: With the OSAHS disease aggravated gradually,patients will have more chances to get coronary heart disease.The main performance is that the risk of single vessel disease for patients will increase.And the left anterior descending artery and right coronary artery is the affected vessels,which may be related to anatomical distribution.Drinking, age, AHI is the main risk factor of coronary artery disease;and drinking, AHI as a single major risk factors for single vessel disease,age is the main risk factor for multiple vessel disease.