The Relationship Between Serum Matrix Metalloproteinase-9(MMP9) Level And Severity Of Coronary Lesions In Premature Acute Coronary Syndrome

Objective: To investigate the relationship between serum matrix metalloproteinase-(MMP-9) level and severity of coronary lesions in Premature Acute Coronary Syndrome(PACS). Methods A total of 131 PACS patients(man’s age≤55years,woman’s age ≤65years) admitted into our hospital between January 2013 and December 2013 were recruited, The case group were also divided into two groups according to median of the modified Gensini score(P50=40)preoperatively.The two groups were severe coronary artery disease group(Gensini score≥40) and moderate coronary artery disease group(Gensini score<40). The control groups were 152 subjects of healthy volunteers respectively. The levels of plasma MMP-9 in venous blood were detected by enzyme-linked immunesorbent assay(ELISA). Results The plasma MMP-9 concentration was significantly higher in case group than in control group(1.46±0.37vs1.07±0.48 mg/L,P<0.001).The plasma MMP-9 concentration increased gradually with the increase of extent of coronary lesions. The serum MMP-9 level in severe coronary artery disease group was higher than moderate coronary artery disease(1.63±0.30vs1.29±0.37 mg/ L, P<0.001). In ROC analysis, Smoking、BMI、MMP-9(>1.47 mg/ L) predicted severe coronary artery disease with 76%sensitivity and 64% specificity. Also,MMP-9(>1.47 mg/ L) was an independent predictor of severe coronary artery disease development(OR=3.123,CI:1.215-6.798, P<0.001). Conclusions:MMP-9 concentration can be a reliable predictive index for severity of coronary lesions in PACS, This parameter could provide useful information for the early risk evaluation on these patients.