| OBJECTIVE:This study aims to investigate the correlation between fracture vitamin, osteocavin of elderly patients with type 2 diabetes mellitus and bone mineral density and osteoporosis.METHODS:From October 2014 to October 2015,103 cases of bone fracture patients with age over 60 are divided into experimental group and control group, experimental group stands for 34 cases of bone fractures with T2DM, control group stands for 69 cases of bone fracture patients without T2DM. Clinical information of both groups were collected, including bone mineral density,laboratory examination results of blood routine, biochemical and laboratory data, such as the bone markers, Clinical data of the two groups.Statistical analysis was using SPSS 13.0 software, data are expressed in (X±S), t test and chi-square test were used in the comparison between the two groups, comparison between multi groups was performed using single factor analysis of variance, and the correlation is analyzed by Pearson analysis, P<0.05 is considered statistically significant.Results:The lumbar spine and hip bone mineral density in experimental group is significantly lower than that in the control group, and the difference is statistically significant (P<0.05); Gender, age, BMI, fasting blood glucose, serum calcium, phosphorus, alkaline phosphatase levels from two groups, and blood uric acid level, alkaline phosphatase and osteocalcin, NLR (neutrophils/lymphocyte ratio), BMI, and serum calcium, phosphorus, showed no difference between experimental and control group (P>0.05); In the experimental group 25 (OH) vitamin D level is significantly lower, and CRP significantly higher, with P<0.05; To compare different levels of vitamin D bone mass group, the comparison of the case group and the control group, bone mass normal group is statistically significant difference (P<0.05), bone loss and osteoporosis group there was no statistical significance (P>0.05) difference comparison, two groups of bone mineral density in patients with osteoporosis, serum 25 (OH) low vitamin D levels were measured with normal group, difference has statistical significance (P<0.05). Different bone mass in patients with serum osteocalcin level comparison, in the case group and the control group, T2DM and the combination of osteoporosis in T2DM patients than in patients with normal bone mass and bone mass reduction of osteocalcin level increased obviously, statistically significant difference (P<0.05), there was no statistically significant difference is compared between two groups (P>0.05). In the experimental group and control group, different fracture positions do not affect the osteocalcin levels in patients, with a P>0.05. Pearson correlation analysis was conducted in patients of bone fracture with T2DM to analyze the correlation of osteocalcin,25 (OH) vitamin D and bone mineral density correlation, hip BMD level. Correlation of 25 (OH) vitamin D (r 0.033, P>0.05), and osteocalcin (r=0.187, P>0.05) with lumbar bone mineral density level; correlation of 25 (OH) vitamin D (r=0.119,P>0.05) and osteocalcin (r=0.076, P>0.05) with lumbar spine. There is a positive correlation between BMD of lumbar spine or hip and 25 (OH) vitamin D; and there is negative correlation between BMD and osteocalcin. But both were not statistically significant (P>0.05).Conclusions:1.The BMD is lower in patients combined T2DM compared with the control group.2. There is a positive correlation between BMD of lumbar spine or hip and 25(OH) vitamin D; and there is negative correlation between BMD and osteocalcin. And both the P values are>0.053. Patients of osteoporosis with T2DM have a low level of 25 (OH) vitamin D, but the Osteocalcin was significantly high.4. Different fracture positions do not affect the levels of osteocalcin. |
PDF Full Text Request