Influence Of Long-time Bed-ridden On Bone Mineral Density And Bone Metabolisms In Elderly Males

Objective To explore the influence of long-time bed-ridden on,bone mineral density,bone metabolisms and incidence of osteoporosis in elderly males.Methods Use historic cohort study,88 patients followed up in Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine during Jan,2011^Aug,2016 were included.The patients were naturally devided into 2 groups,exposure group?bed-ridden group,45patients,without the ability of self-care since 2011?and nonexposure group?control group,43patients?then follow up 5 years,until Aug,2016,observe the BMD of the lumbar,and bone metabolic markers?OC,?-CTX,P1NP,25?OH?D₃,PTH?to explore the influence of long-time bed-ridden on incidence of osteoporosis and fracture.Results 1.At starting point,the general clinical data showed no significant difference between two groups?P>0.05?.At endpoint of the study,the BMI?22.92 vs 24.24?,BMD of the lumbar?1.04g/cm² vs1.14g/cm²?,25?OH?D₃ level?12.13ng/mL vs16.98 ng/mL?of exposure group were lower than nonexposure group.Other general clinical data showed no significant difference in two groups?P>0.05?.2.BMD of the lumbar in exposure group at endpoint was lower than at starting point?1.13g/cm² vs1.04g/cm²,P<0.05?and no significant difference in bone metabolic markers?P>0.05?.The level of the serum OC,?-CTX,P1NP of nonexposure group at endpoint were higher than starting point?12.11ng/mL vs 14.34ng/mL,0.25ng/mL vs 0.37ng/mL,33.74ng/mL vs 51.06ng/mL,P<0.05?,but no significant difference in BMD of the lumbar,25?OH?D₃,PTH?P>0.05?.3.In the duration of the study,incidence rate of osteoporosis in exposure group was higherthannonexposuregroup?22.22%vs6.98%,P<0.05?and RR=3.185?95%CI 1.025⁹.894?,AR=0.152,and no difference of fracture between two groups?P>0.05?.4.The age,BMI,diabetes mellitus,long-time bed-ridden,serum creatinine level were related to BMD of the lumbar?r=-0.309,0.394,-0.221,-0.451,0.205,P<0.05?and age,BMI,bed-ridden were independent correlative factors of BMD?P<0.05?.Conclusion The synergistic action of long-time bed-ridden,worse nutritional condition and the lose of BMI result in decreasing of BMD of the lumbar and rising in incidence rate of osteoporosis in elderly males.