| Chapter one Age- and menopause-dependent changes of serum bone alkaline phosphatase, osteocalcin, cross-linked N-telopeptides of type I collagen, urinary deoxypyridinoline and bone mineral densityin Changsha femalesObjective To determine how the biochemical markers as serum bone alkaline phosphatase(B-ALP), osteocalcin(OC), cross-linked N-telopeptides of type I collagen(NTX), urinary deoxypyridinoline(DPD), and BMD are varied with age and menopause, and to evaluate the correlationship between them in 895 Changsha women aged 20～80 years.Subjects and Methods Bone turnover level was assessed by measuring B-ALP, OC, NTX, and DPD. Serum B-ALP and OC were used to evaluate the bone formation status; while serum NTX and urinary DPD were used to detect the status of bone resorption. Dual-energy x-ray absorptiometry (DXA) was used to measure BMD at the lumbar spine from L1-L4, hip and distal end of radius and ulna. Results It was found that a cubic regression model provided the best fit for serum B-ALP, OC, NTX and urinary DPD (R~2=0.060～0.340, p=0.000) to various ages in women as compared with other 9 regression models. Bone turnover status reached a minimal level in the age range of 30～39 years, when a peak bone mass was acquired at posteroanterior spine. During the age range of 40～59 years, the level of bone turnover increased significantly, accompanied by a decrease in BMD at multiple skeletal regions. Compared with premenopausal women, perimenopausal women were associated with increased levels of serum B-ALP, OC, NTX, and urinary DPD and decreased values of BMD at several skeletal regions including lumber spine and hip (P=0.004～0.000). After menopause, the serum B-ALP, OC, and NTX were increased while BMD at most skeletal regions including lumber spine, hip, and distal end of radius and ulna were further dereased (P=0.027～0.000). With the correction for age, height, body weight and body mass index (BMI), the values of serum B-ALP, OC, NTX and urinary DPD were correlated...
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