A System-Level Investigation Into The Mechanisms Of Chinese Traditional Medicine: Zingiber Officinale Roscoe

Trditional Chinese Medicine(TCM) with its focus on herbal application became popular in the worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. Traditional Chinese Medicine is the treasure full of the splendid culture for Chinese nation, moreover, it’s theory essence of the and clinical medicine practice experience of doctors through several thousand years. Polypharmacy is the biggest characteristic, based on the guidance of the basic theory of Trditional Chinese Medicine to form the Chinese compound prescription through combination different medicinal herbs. However, because of the shortage of the traditional research methods, it is still difficult to understand the mechanism of Trditional Chinese Medicine in the molecular level. Therefore, in this study, to decipher the mechanism of Traditional Chinese Medicine, we set up a systemic pharmacological assessment on Traditional Chinese Medicine. ADME screening, potential target predition, disease analysis and network pharmacology analysis is included.Ginger(Zingiber officinale Roscoe), one of the most common Chinese herbal medicine, is native in southeast Asia,and its planting history is more than thousands of years. Due to its anti-tumor, anti-inflammatory effect, ginger has been widely used. In this study, to investigate the pharmacological properties of ginger, we established a new model including oral bioavailability evaluation, drug-likeness properties evaluation, barrier permeability of blood brain, permeability of human intestinal cells, target protein prediction and subsequent topology analysis. The main results were as follows:(1) Through the oral availability, drug-likenes, the absorption selection of blood-brain barrier and intestinal, there are 26 compounds in ginger were identified as effective active ingredients, including ones reported in the literature: zingiberol, zingiberene, phellandrene, camphene, citral, linalool, methylheptenone, nonylaldehyde, d- borneol etc, which further proves the rationality with the model. In addition, the compound campesterol also be identified as potential drugs of ginger.(2) The 57 targets related to various diseases play key roles in the pharmacological mechanism rsearch, and the drug- target network reveals: Molecule 024(methyl-6-gingerol), Molecule 007(1,7-diphenyl-5-hydroxy-3-heptanone) and the target protein VDR, RXRA, STS has a relatively high degree and betweenness values, they are play significant roles in the drug – target network.(3) By the biological analysis, we find that ginger has a good therapeutic effect on the diseases in the digestive system, respiratory system disease, and central nervous system.