| With the aging of our population, diabetes incidence rate assumes the trend of escalation, the common complications of diabetes was significantly increased in patients with diabetic nephropathy, early symptoms is not obvious, microalbuminuria of easily overlooked, once in the clinical stage diabetic nephropathy(DN),pathological process difficult to reverse can only reduce the symptoms of the disease and to protect renal function, prevention and treatment of complications of the corresponding main, delaying diabetic nephropathy to final end-stage renal disease(ESRD) curative effect progress Co.The motherland medicine is broad and profound,has many single medicine and the prescription traditional Chinese medicine treatment on the successful experience of the diabetic nephropathy, but the Chinese medicine treatment mechanism research report is limited. The aim of this study was to observe the composition of the clear of Rhadiola extract injection, changes of clinical common Qi deficiency and blood stasis type diabetic nephropathy oxidative stress index and clinical examination index, intends to and to investigate the pathogenesis of diabetic nephropathy, to provide the clinical basis for the expansion of the treatment of diabetic nephropathy.Purpose: through the large strain of rhodiola treatment of qi deficiency and blood stasis type diabetes nephrosis patient’s clinical observation and data analysis,compared before and after treatment of oxygen factor 1 alpha(HIF- 1 a), thioredoxin(Trx), endogenous erythropoietin(EPO), and the change of clinical indicators, to explore the therapeutic mechanism of large strain of rhodiola on diabetic nephropathy,excavate the therapeutic effect of large strain of rhodiola for extended scope of treatment plants of rhodiola rosea, provide clinical theory basis.Methods: 60 cases, by random number method divided the patients into the treatment group and control group, treatment group 30 cases and control group 30 cases.The control group used western medicine treatment system;Treatment group on the basis of western medicine treatment system combined with large plant rhodiola injection treatment, the treatment for 14 days(course is more than 12 days, cases can be included in the statistics).Were observed before and after treatment of traditional Chinese medicine qi deficiency and blood stasis syndrome(fatigue, swelling, skin complexion, god a fault, etc.) change, both before and after the treatment of urinary inhibition detection of serum C(Cys C) and hypoxia inducing factor- 1 alpha(HIF- 1a), thioredoxin(Trx), endogenous erythropoietin(EPO), hypersensitive c-reactive protein(hs CRP) and glycosylated hemoglobin(Hb A1c), blood uric acid(UAER),blood urea nitrogen(BUN), serum creatinine(SCr), urine micro protein(m ALBU),alpha 1 microglobulin(alpha1-MU), transferrin(TRFU), Ig G protein(Ig G), 24 hours urinary protein quantitative(Upr), and compare the two groups before and after treatment index change and index of two groups after treatment have obvious difference.Results:?In the treatment group, the total effective rate was 83.33%, and there was a difference between the control group and the control group(P<0.05); ? The improvement rate of TCM symptoms in the treatment group was 80%, which was significantly different from that in the control group(P<0.01);?After the treatment of two groups of TCM syndrome type and before treatment compared with the difference(P<0.05), two groups after treatment, the treatment group to improve Qi deficiency and blood stasis symptoms compared with the control group there is significant difference(P<0.01);(4)In treatment group, lusterless complexion, fatigued spirit and lack of strength, less gas lazy words, fixed low back pain,squamous and dry skin, paraesthesia curative effect is obviously superior to the control group(P<0.01),the treatment group improvement of edema symptoms curative effect is better than that of the control group(P<0.05). The two groups of turbid urine without significantly improved(P>0.05);(5)After treatment, two groups of fasting blood glucose was decreased significantly(P<0.01), treatment group hypoglycemic effect isbetter than that of the control group(P<0.05), before and after treatment in the two groups of glycosylated hemoglobin decreased, but no statistical significance(P>0.05);(6)After treatment, the two groups TG, TC than before treatment were significantly decreased(P<0.01), the treatment group was better than the control group(P<0.05), the two groups before and after the comparison of hs-CRP no significant change(P>0.05);(7)The two groups after treatment, SCr, SUA, Cys C than before significantly decreased, GFR was significantly higher than before(P<0.05), the treatment group improved renal function than the control group(P<0.05);(8)After treatment, the treatment group alpha 1-MU and TRFU compared with the previous declined(P<0.05), m ALBU and Ig G declined over the former, but no statistical significance(P>0.05). After the control treatment group, alpha 1-MU, TRFU,m ALBU, alpha 1-MU protein were no significant difference(P>0.05);(9)After the treatment of the two groups, there was no significant change in Upr(P>0.05);(10)After treatment, the two groups of HIF-1a were significantly decreased, Trx and endogenous EPO were significantly higher than before treatment(P<0.01), the treatment group was better than the control group(P<0.05).Conclusion: 1.Rhodiola wallichiana can significantly improve the renal function of diabetic nephropathy;2.Rhodiola wallichiana can significantly improve the symptoms of diabetes and kidney qi deficiency and blood stasis;3.Rhodiola wallichiana can improve blood glucose, blood lipid, urinary 1-MU and TRFU and other indicators;4.Rhodiola wallichiana may improve the renal function of diabetic nephropathy by inhibiting the expression of the intermediate products of some oxidative stress, and delay the progression of the disease;5.Rhodiola wallichiana not only improve the renal function of diabetic nephropathy, but also has the improvement of diabetic nephropathy patients with Qi deficiency, blood stasis and other symptoms of traditional Chinese medicine curative effect, it is worth further development and application. |
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