Relation Of Netrophil/Lymphocyte Ratio To Coronary Blood Flow In Patients With Non-ST-Segment Elevation Acute Coronary Syndronmes

Objective:To investigate the relationship of neutrophil/lymphocyte ratio(NLR) and coronary blood flow in patents with non-ST-stegmnent elevation acute coronary syndromes(NSTE-ACS) undergoing primary percutaneous coronary intervention(PCI).Methods:In the current study,104 patents treatd with primary PCI in the first Comprehensive Ward of Guangxi Zhuang Autonomous Region People’s Hospital from 2013 to 2016,were divided into two groups base on the coronary blood flow before PCI, the normal flow group(TIMI 3,n=57) and abnormal flow group(TIMI<2,n=47).Receiver operating characteristic cure(ROC) was used to evaluate the cut-off point of NLR aboat abnormal coronary blood flow,and multivariate logistic regession was used to assessed the independent predictor for abnormal coronary blood flow.All statistical calculations and analyses were performed by using SPSS 17.0.Results:To compare with the normal flow group,NLR was higher in the abnormal flow group(3.13±1.86 vs.2.07±0.82,P<0.001).In the ROC anlysis,a cut-off NLR of 2.28 predicted abnormal coronary blood flow with a sensitivity and specificity of 63.8% and 36.8%, more over,the positive predictive value and negative predictive value are 50.2%、50.4%. Multivariate logistic regession anlysis showed that for those men who was sufuring NSTE-ACS,NLR remained an independent predictor for abnormal coronary blood flow before primary PCI (OR=3.28,95%CI:1.085～9.897,P=0.035), after adjustment for age, genger, hypertension, diabetes, white blood cell,neutrophil,monocyte,fibrinogen,ejection fraction and non-ST-stegmnent elevation acute coronary syndromes.Conclusion:NLR was an independent prector for abnormal coronary blood flow in NSTE-ACS patients befor the primary PCI.